Effects of hypochlorhydria and hypergastrinemia on structure and function of gastrointestinal cells - A review and analysis

James W. Freston, Kurt Borch, Stephen J. Brand, Enar Carlsson, W. Creutzfeldt, Rolf Håkanson, Lars Olbe, Enrico Solcia, John H. Walsh, M. Michael Wolfe

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Since hypochlorhydria can induce hypergastrinemia, and gastrin has a trophic effect on some gastrointestinal cells, states that cause elevated plasma gastrin levels are of interest in terms of effects on cell growth and function. This article reviews the relationship between gastric mucosal cells during periods of acid stimulation and inhibition and analyses the effects of hypochlorhydria and hypergastrinemia on gastric and colonic cells and tumors. Hypochlorhydria releases the inhibitory effect of antral gastrin cells, inducing them to release gastrin in the presence of peptides or amino acids in the gastric lumen or in response to antral distension. Gastrin stimulates the oxyntic mucosa, which may lead to hyperplasia of enterochromaffin-like cells, resulting in enterochromaffin-like carcinoid tumors in aged rats and, rarely, in patients with chronic atrophic gastritis or gastrinomas. In addition to hypergastrinemia, other factors appear to be required for the progression of enterochromaffin-like hyperplasia to carcinoids; genetic factors may be involved. Gastrin elevations due to antisecretory drug therapy are indirectly proportional to the degree of acid inhibition and are reversible upon cessation of therapy. The gastrin levels during omeprazole therapy are similar to those caused by gastric vagotomy. Available evidence does not support a relationship between hypergastrinemia and the occurrence or growth of gastric carcinoma or colonic tumors.

Original languageEnglish
JournalDigestive Diseases and Sciences
Volume40
Issue number2 Supplement
DOIs
Publication statusPublished - Feb 1995

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Achlorhydria
Gastrins
Stomach
Carcinoid Tumor
Hyperplasia
Enterochromaffin-like Cells
Gastrinoma
Atrophic Gastritis
Gastrin-Secreting Cells
Acids
Omeprazole
Vagotomy
Growth
Neoplasms
Mucous Membrane
Carcinoma
Amino Acids
Drug Therapy
Peptides
Therapeutics

Keywords

  • enterochromaffin-like cell carcinoids
  • hypergastrinemia
  • hypochlorhydria
  • omeprazole
  • peptic ulcer

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Freston, J. W., Borch, K., Brand, S. J., Carlsson, E., Creutzfeldt, W., Håkanson, R., ... Michael Wolfe, M. (1995). Effects of hypochlorhydria and hypergastrinemia on structure and function of gastrointestinal cells - A review and analysis. Digestive Diseases and Sciences, 40(2 Supplement). https://doi.org/10.1007/BF02214871

Effects of hypochlorhydria and hypergastrinemia on structure and function of gastrointestinal cells - A review and analysis. / Freston, James W.; Borch, Kurt; Brand, Stephen J.; Carlsson, Enar; Creutzfeldt, W.; Håkanson, Rolf; Olbe, Lars; Solcia, Enrico; Walsh, John H.; Michael Wolfe, M.

In: Digestive Diseases and Sciences, Vol. 40, No. 2 Supplement, 02.1995.

Research output: Contribution to journalArticle

Freston, JW, Borch, K, Brand, SJ, Carlsson, E, Creutzfeldt, W, Håkanson, R, Olbe, L, Solcia, E, Walsh, JH & Michael Wolfe, M 1995, 'Effects of hypochlorhydria and hypergastrinemia on structure and function of gastrointestinal cells - A review and analysis', Digestive Diseases and Sciences, vol. 40, no. 2 Supplement. https://doi.org/10.1007/BF02214871
Freston, James W. ; Borch, Kurt ; Brand, Stephen J. ; Carlsson, Enar ; Creutzfeldt, W. ; Håkanson, Rolf ; Olbe, Lars ; Solcia, Enrico ; Walsh, John H. ; Michael Wolfe, M. / Effects of hypochlorhydria and hypergastrinemia on structure and function of gastrointestinal cells - A review and analysis. In: Digestive Diseases and Sciences. 1995 ; Vol. 40, No. 2 Supplement.
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