Effects of hypotensive doses of prostaglandin A1 on plasma glucose, free fatty acids and insulin in reserpinized dogs

Luigi Saccà; F. Rengo; G. Perez; M. Chiariello; M. Condorelli

doi:10.1159/000136380

Effects of hypotensive doses of prostaglandin A₁ on plasma glucose, free fatty acids and insulin in reserpinized dogs

Luigi Saccà, F. Rengo, G. Perez, M. Chiariello, M. Condorelli

Istituti Clinici Scientifici Maugeri Spa – Società Benefit

Research output: Contribution to journal › Article › peer-review

Abstract

Intravenous infusion of prostaglandin A₁ at hypotensive dosage into reserpinized dogs increased plasma glucose and FFA levels and lowered the rate of glucose disappearance following glucose loading. Total insulin response was enhanced while insulinogenic index was not significantly affected by PGA₁. The role of the adrenergic system as mediator of the foregoing metabolic effects of PGA₁ is discussed.

Original language	English
Pages (from-to)	159-163
Number of pages	5
Journal	Pharmacology
Volume	9
Issue number	3
DOIs	https://doi.org/10.1159/000136380
Publication status	Published - 1973

Keywords

Free fatty acids
Glucose
Insulin
Prostaglandin A<inf>1</inf>
Reserpine

ASJC Scopus subject areas

Pharmacology

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