Effects of hypotensive doses of prostaglandin A1 on plasma glucose, free fatty acids and insulin in reserpinized dogs

Luigi Saccà, F. Rengo, G. Perez, M. Chiariello, M. Condorelli

Research output: Contribution to journalArticlepeer-review

Abstract

Intravenous infusion of prostaglandin A1 at hypotensive dosage into reserpinized dogs increased plasma glucose and FFA levels and lowered the rate of glucose disappearance following glucose loading. Total insulin response was enhanced while insulinogenic index was not significantly affected by PGA1. The role of the adrenergic system as mediator of the foregoing metabolic effects of PGA1 is discussed.

Original languageEnglish
Pages (from-to)159-163
Number of pages5
JournalPharmacology
Volume9
Issue number3
DOIs
Publication statusPublished - 1973

Keywords

  • Free fatty acids
  • Glucose
  • Insulin
  • Prostaglandin A<inf>1</inf>
  • Reserpine

ASJC Scopus subject areas

  • Pharmacology

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