Effects of ibopamine on heart performance: A radionuclide ventriculography study in patients with idiopathic dilatative cardiomyopathy

E. Gronda, B. Brusoni, E. Inglese, M. Mangiavacchi, M. Gasparini, P. Ghirardi

Research output: Contribution to journalArticlepeer-review

Abstract

The effects of ibopamine (SB-7505, Ib), a new orally active 3,4-diisobutyryl ester of N-methyldopamine, were studied in 8 patients aged between 34-56 years with idiopathic dilatative cardiomyopathy (II-III New York Heart Association Class) diagnosed by means of right and left heart catheterization and selective coronary angiography. Equilibrium radionuclide ventriculography (RVG) was performed in baseline conditions and 1, 2, and 3 h after the administration of a single oral dose of 200-300 mg of Ib. After 2 h Ib increased cardiac output (CO) (+16%, p <0.05), stroke volume (SV) (+12%, p <0.05) and ejection fraction (EF) (+10%, p <0.01). Patients were then randomly treated with placebo or Ib 100 mg t.i.d. according to a double-blind cross-over design for two periods of 15 days each. At the end of each period of RVG was repeated in baseline conditions and 1, 2, and 3 h thereafter. The mean values of the four determinations were higher after Ib than after placebo (CO: +10.1%, p <0.01; SV: +14.1%, p <0.01; EF: +10.8%, p <0.05). Patients subsequently started a long-term treatment with Ib 100 mg t.i.d.; after 6 months patients underwent RVG 3 h after the last dose of Ib: compared with the values recorded at the same time after the short-term treatment, CO further increased by 17% (NS), SV by 22% (p <0.05) and EF by 24% (p <0.05). The treatment was well tolerated. These results seem to indicate that Ib can acutely improve left ventricular function in patients with congestive heart failure, and that these effects are maintained after short- and long-term treatment.

Original languageEnglish
Pages (from-to)371-375
Number of pages5
JournalArzneimittel-Forschung/Drug Research
Volume36
Issue number2 A
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

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