Abstract
Cytokines are promising agents for cancer therapy due to their activity at low concentrations. We used a naked IL-12 DNA expression vector to achieve long-term systemic cytokine expression to inhibit breast tumor growth in MMTVneu transgenic and transplanted models. Constant low levels of IL-12 produced by this protocol provided effective tumor growth inhibition of both tumor models without adverse effects.
| Original language | English |
|---|---|
| Pages (from-to) | 223-226 |
| Number of pages | 4 |
| Journal | Breast Cancer Research and Treatment |
| Volume | 110 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jul 2008 |
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Keywords
- Gene therapy
- IL-12
- MMTVneu
- Transgenic mice
- Transplanted breast tumors
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Effects of IL-12 gene therapy on spontaneous transgenic and transplanted breast tumors. / Faggioli, Francesca; Soldati, Sabina; Scanziani, Eugenio; Catò, Enrica Mira; Adorni, Fulvio; Vezzoni, Paolo; Noonan, Douglas M.; Sacco, Maria Grazia.
In: Breast Cancer Research and Treatment, Vol. 110, No. 2, 07.2008, p. 223-226.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of IL-12 gene therapy on spontaneous transgenic and transplanted breast tumors
AU - Faggioli, Francesca
AU - Soldati, Sabina
AU - Scanziani, Eugenio
AU - Catò, Enrica Mira
AU - Adorni, Fulvio
AU - Vezzoni, Paolo
AU - Noonan, Douglas M.
AU - Sacco, Maria Grazia
PY - 2008/7
Y1 - 2008/7
N2 - Cytokines are promising agents for cancer therapy due to their activity at low concentrations. We used a naked IL-12 DNA expression vector to achieve long-term systemic cytokine expression to inhibit breast tumor growth in MMTVneu transgenic and transplanted models. Constant low levels of IL-12 produced by this protocol provided effective tumor growth inhibition of both tumor models without adverse effects.
AB - Cytokines are promising agents for cancer therapy due to their activity at low concentrations. We used a naked IL-12 DNA expression vector to achieve long-term systemic cytokine expression to inhibit breast tumor growth in MMTVneu transgenic and transplanted models. Constant low levels of IL-12 produced by this protocol provided effective tumor growth inhibition of both tumor models without adverse effects.
KW - Gene therapy
KW - IL-12
KW - MMTVneu
KW - Transgenic mice
KW - Transplanted breast tumors
UR - http://www.scopus.com/inward/record.url?scp=44849142071&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=44849142071&partnerID=8YFLogxK
U2 - 10.1007/s10549-007-9713-6
DO - 10.1007/s10549-007-9713-6
M3 - Article
C2 - 17687642
AN - SCOPUS:44849142071
VL - 110
SP - 223
EP - 226
JO - Breast Cancer Research and Treatment
JF - Breast Cancer Research and Treatment
SN - 0167-6806
IS - 2
ER -