Effects of IL-12 gene therapy on spontaneous transgenic and transplanted breast tumors

Francesca Faggioli; Sabina Soldati; Eugenio Scanziani; Enrica Mira Catò; Fulvio Adorni; Paolo Vezzoni; Douglas M. Noonan; Maria Grazia Sacco

doi:10.1007/s10549-007-9713-6

Effects of IL-12 gene therapy on spontaneous transgenic and transplanted breast tumors

Francesca Faggioli, Sabina Soldati, Eugenio Scanziani, Enrica Mira Catò, Fulvio Adorni, Paolo Vezzoni, Douglas M. Noonan, Maria Grazia Sacco

Research output: Contribution to journal › Article › peer-review

Abstract

Cytokines are promising agents for cancer therapy due to their activity at low concentrations. We used a naked IL-12 DNA expression vector to achieve long-term systemic cytokine expression to inhibit breast tumor growth in MMTVneu transgenic and transplanted models. Constant low levels of IL-12 produced by this protocol provided effective tumor growth inhibition of both tumor models without adverse effects.

Original language	English
Pages (from-to)	223-226
Number of pages	4
Journal	Breast Cancer Research and Treatment
Volume	110
Issue number	2
DOIs	https://doi.org/10.1007/s10549-007-9713-6
Publication status	Published - Jul 2008

Keywords

Gene therapy
IL-12
MMTVneu
Transgenic mice
Transplanted breast tumors

ASJC Scopus subject areas

Oncology
Cancer Research

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Effects of IL-12 gene therapy on spontaneous transgenic and transplanted breast tumors. / Faggioli, Francesca; Soldati, Sabina; Scanziani, Eugenio; Catò, Enrica Mira; Adorni, Fulvio; Vezzoni, Paolo ; Noonan, Douglas M.; Sacco, Maria Grazia.

In: Breast Cancer Research and Treatment, Vol. 110, No. 2, 07.2008, p. 223-226.

Research output: Contribution to journal › Article › peer-review

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