Effects of IL-12 gene therapy on spontaneous transgenic and transplanted breast tumors

Francesca Faggioli, Sabina Soldati, Eugenio Scanziani, Enrica Mira Catò, Fulvio Adorni, Paolo Vezzoni, Douglas M. Noonan, Maria Grazia Sacco

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Cytokines are promising agents for cancer therapy due to their activity at low concentrations. We used a naked IL-12 DNA expression vector to achieve long-term systemic cytokine expression to inhibit breast tumor growth in MMTVneu transgenic and transplanted models. Constant low levels of IL-12 produced by this protocol provided effective tumor growth inhibition of both tumor models without adverse effects.

Original languageEnglish
Pages (from-to)223-226
Number of pages4
JournalBreast Cancer Research and Treatment
Volume110
Issue number2
DOIs
Publication statusPublished - Jul 2008

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Interleukin-12
Genetic Therapy
Breast Neoplasms
Cytokines
Neoplasms
Growth
DNA
Therapeutics

Keywords

  • Gene therapy
  • IL-12
  • MMTVneu
  • Transgenic mice
  • Transplanted breast tumors

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Effects of IL-12 gene therapy on spontaneous transgenic and transplanted breast tumors. / Faggioli, Francesca; Soldati, Sabina; Scanziani, Eugenio; Catò, Enrica Mira; Adorni, Fulvio; Vezzoni, Paolo; Noonan, Douglas M.; Sacco, Maria Grazia.

In: Breast Cancer Research and Treatment, Vol. 110, No. 2, 07.2008, p. 223-226.

Research output: Contribution to journalArticle

Faggioli, Francesca ; Soldati, Sabina ; Scanziani, Eugenio ; Catò, Enrica Mira ; Adorni, Fulvio ; Vezzoni, Paolo ; Noonan, Douglas M. ; Sacco, Maria Grazia. / Effects of IL-12 gene therapy on spontaneous transgenic and transplanted breast tumors. In: Breast Cancer Research and Treatment. 2008 ; Vol. 110, No. 2. pp. 223-226.
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