Effects of IL-12 gene therapy on spontaneous transgenic and transplanted breast tumors

Francesca Faggioli, Sabina Soldati, Eugenio Scanziani, Enrica Mira Catò, Fulvio Adorni, Paolo Vezzoni, Douglas M. Noonan, Maria Grazia Sacco

Research output: Contribution to journalArticlepeer-review

Abstract

Cytokines are promising agents for cancer therapy due to their activity at low concentrations. We used a naked IL-12 DNA expression vector to achieve long-term systemic cytokine expression to inhibit breast tumor growth in MMTVneu transgenic and transplanted models. Constant low levels of IL-12 produced by this protocol provided effective tumor growth inhibition of both tumor models without adverse effects.

Original languageEnglish
Pages (from-to)223-226
Number of pages4
JournalBreast Cancer Research and Treatment
Volume110
Issue number2
DOIs
Publication statusPublished - Jul 2008

Keywords

  • Gene therapy
  • IL-12
  • MMTVneu
  • Transgenic mice
  • Transplanted breast tumors

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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