Abstract
Cytokines are promising agents for cancer therapy due to their activity at low concentrations. We used a naked IL-12 DNA expression vector to achieve long-term systemic cytokine expression to inhibit breast tumor growth in MMTVneu transgenic and transplanted models. Constant low levels of IL-12 produced by this protocol provided effective tumor growth inhibition of both tumor models without adverse effects.
Original language | English |
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Pages (from-to) | 223-226 |
Number of pages | 4 |
Journal | Breast Cancer Research and Treatment |
Volume | 110 |
Issue number | 2 |
DOIs | |
Publication status | Published - Jul 2008 |
Keywords
- Gene therapy
- IL-12
- MMTVneu
- Transgenic mice
- Transplanted breast tumors
ASJC Scopus subject areas
- Oncology
- Cancer Research