Effects of IL-12 gene therapy on spontaneous transgenic and transplanted breast tumors

Francesca Faggioli; Sabina Soldati; Eugenio Scanziani; Enrica Mira Catò; Fulvio Adorni; Paolo Vezzoni; Douglas M. Noonan; Maria Grazia Sacco

doi:10.1007/s10549-007-9713-6

Effects of IL-12 gene therapy on spontaneous transgenic and transplanted breast tumors

Francesca Faggioli, Sabina Soldati, Eugenio Scanziani, Enrica Mira Catò, Fulvio Adorni, Paolo Vezzoni, Douglas M. Noonan, Maria Grazia Sacco

Research output: Contribution to journal › Article › peer-review

Abstract

Cytokines are promising agents for cancer therapy due to their activity at low concentrations. We used a naked IL-12 DNA expression vector to achieve long-term systemic cytokine expression to inhibit breast tumor growth in MMTVneu transgenic and transplanted models. Constant low levels of IL-12 produced by this protocol provided effective tumor growth inhibition of both tumor models without adverse effects.

Original language	English
Pages (from-to)	223-226
Number of pages	4
Journal	Breast Cancer Research and Treatment
Volume	110
Issue number	2
DOIs	https://doi.org/10.1007/s10549-007-9713-6
Publication status	Published - Jul 2008

Keywords

Gene therapy
IL-12
MMTVneu
Transgenic mice
Transplanted breast tumors

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1007/s10549-007-9713-6

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title = "Effects of IL-12 gene therapy on spontaneous transgenic and transplanted breast tumors",

abstract = "Cytokines are promising agents for cancer therapy due to their activity at low concentrations. We used a naked IL-12 DNA expression vector to achieve long-term systemic cytokine expression to inhibit breast tumor growth in MMTVneu transgenic and transplanted models. Constant low levels of IL-12 produced by this protocol provided effective tumor growth inhibition of both tumor models without adverse effects.",

keywords = "Gene therapy, IL-12, MMTVneu, Transgenic mice, Transplanted breast tumors",

author = "Francesca Faggioli and Sabina Soldati and Eugenio Scanziani and Cat{\`o}, {Enrica Mira} and Fulvio Adorni and Paolo Vezzoni and Noonan, {Douglas M.} and Sacco, {Maria Grazia}",

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language = "English",

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AU - Faggioli, Francesca

AU - Soldati, Sabina

AU - Scanziani, Eugenio

AU - Catò, Enrica Mira

AU - Adorni, Fulvio

AU - Vezzoni, Paolo

AU - Noonan, Douglas M.

AU - Sacco, Maria Grazia

PY - 2008/7

Y1 - 2008/7

N2 - Cytokines are promising agents for cancer therapy due to their activity at low concentrations. We used a naked IL-12 DNA expression vector to achieve long-term systemic cytokine expression to inhibit breast tumor growth in MMTVneu transgenic and transplanted models. Constant low levels of IL-12 produced by this protocol provided effective tumor growth inhibition of both tumor models without adverse effects.

AB - Cytokines are promising agents for cancer therapy due to their activity at low concentrations. We used a naked IL-12 DNA expression vector to achieve long-term systemic cytokine expression to inhibit breast tumor growth in MMTVneu transgenic and transplanted models. Constant low levels of IL-12 produced by this protocol provided effective tumor growth inhibition of both tumor models without adverse effects.

KW - Gene therapy

KW - IL-12

KW - MMTVneu

KW - Transgenic mice

KW - Transplanted breast tumors

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JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

SN - 0167-6806

IS - 2

ER -

Effects of IL-12 gene therapy on spontaneous transgenic and transplanted breast tumors

Abstract

Keywords

ASJC Scopus subject areas

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