Effects of imidazole-salicylate on renal function and the diuretic action of furosemide in cirrhotic patients with ascites

Francesco Salerno, Elettra Lorenzano, Alessandra Maggi, Salvatore Badalamenti, Piero Minuz, Maurizio Degan, Benito Chinea, Aurelio Scotti

Research output: Contribution to journalArticlepeer-review

Abstract

Imidazole-salicylate is a non-steroidal anti-inflammatory drug with limited inhibitory effects on prostaglandin synthesis. The renal effects of this drug were investigated by a double-blind corss-over study in 10 patients with cirrhosis and ascites. Two therapeutic doses of imidazole-salicylate (750 mg each) were given at midnight and 08:00 h and 80 mg of furosemide were injected intravenously at 09:00 h. The same procedure was followed on another day but a placebo replaced imidazole-salicylate. Renal function (creatinine clearance, free water and electrolyte excretions) and urinary excretion of prostaglandin E, 6-keto-prostaglandin F and thromboxane B2 were evaluated for 8 h after the first dose of the drug and for 2 h after furosemide injection. Platelet thromboxane production was also determined 9 h after the first administration of drug or placebo. Imidazole-salicylate did not affect renal function or inhibit kidney prostanoid production either under basal conditions or after the stimulating effect of furosemide. On the contrary, imidazole-salicylate significantly inhibited platelet thromboxane production (45.8 ± 9 vs. 69.4 ± 7.5 ng/ml, P <0.05). These results suggest that imidazole-salicylate is an anti-inflammatory drug that can be given to patients with decompensated cirrhosis without risk of inhibiting kidney prostaglandin synthesis or the renal response to furosemide.

Original languageEnglish
Pages (from-to)279-284
Number of pages6
JournalJournal of Hepatology
Volume19
Issue number2
DOIs
Publication statusPublished - 1993

Keywords

  • Diuretics
  • Non-steroidal anti-inflammatory drugs
  • Prostaglandins
  • Thromboxane

ASJC Scopus subject areas

  • Gastroenterology

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