Effects of immobilization stress on dopamine and its metabolites in different brain areas of the mouse: role of genotype and stress duration

Simona Cabib, Eliane Kempf, Carmen Schleff, Alberto Oliverio, Stefano Puglisi-Allegra

Research output: Contribution to journalArticle

92 Citations (Scopus)

Abstract

Immobilization stress induced, in mice of both C57BL/6 (C57) and DBA/2 (DBA) strains, an increase in dihydroxyphenylacetic acid (DOPAC)/dopamine (DA) and homovanillic acid (HVA)/DA ratios and a reduction of 3-methoxytyramine (3-MT)/DA ratio in the caudatus putamen (CP) and nucleus accumbens septi (NAS). These effects were already evident after 30 min stress in the NAS, while in the CP 120 min were needed in order to show the effects of stress. Immobilization did not produce any effects on dopaminergic metabolism in the frontal cortex (FC) of the C57 strain either after 30 or after 120 min stress while in mice of the DBA strain a time-dependent effect of stress on the HVA/DA ratio was evident. When B6D2F1 hybrids were considered, the effects produced by 120 min immobilization in the CP and the NAS paralleled those observed in parental strains, while in the FC 120 min stress indcued the same increase of HVA observed in DBA mice, thus suggesting that the pattern of response in the FC that characterizes the DBA strain may be inherited through a dominant pattern of inheritance.

Original languageEnglish
Pages (from-to)153-160
Number of pages8
JournalBrain Research
Volume441
Issue number1-2
DOIs
Publication statusPublished - Feb 16 1988

Fingerprint

Immobilization
Homovanillic Acid
Caudate Nucleus
Putamen
Dopamine
Nucleus Accumbens
Frontal Lobe
Genotype
Inbred DBA Mouse
Brain
Inheritance Patterns
Inbred C57BL Mouse
Acids

Keywords

  • 3-Methoxytyramine
  • Brain area
  • Dihydroxyphenylacetic acid
  • Dopamine
  • Genotype
  • Homovanillic acid
  • Mouse
  • Stress

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Effects of immobilization stress on dopamine and its metabolites in different brain areas of the mouse : role of genotype and stress duration. / Cabib, Simona; Kempf, Eliane; Schleff, Carmen; Oliverio, Alberto; Puglisi-Allegra, Stefano.

In: Brain Research, Vol. 441, No. 1-2, 16.02.1988, p. 153-160.

Research output: Contribution to journalArticle

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