Abstract
The effects of inactivated streptococci (OK-432) on murine macrophage functions were investigated. In vivo treatment of peritoneal macrophages with OK-432 augmented the direct cytotoxic activity against TU5 tumor cells in a 48 h tritiated thymidine release assay. OK-432 also stimulated the rapid (6 h, 51Cr release) macrophage-mediated killing of Actinomycin D-sensitized WEHI 164 sarcoma cells. Moreover, the expression of Ia antigens on peritoneal macrophages was found to be greatly enhanced after in vivo treatment with OK-432. The immunomodulatory effects of OK-432 on macrophages functions may contribute to the antitumor activity of inactivated streptococci.
| Original language | English |
|---|---|
| Pages (from-to) | 437-449 |
| Number of pages | 13 |
| Journal | Journal of Immunopharmacology |
| Volume | 7 |
| Issue number | 4 |
| Publication status | Published - 1985 |
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ASJC Scopus subject areas
- Immunology
- Toxicology
- Pharmacology
Cite this
Colotta, F., Bersani, L., Polentarutti, N., Peri, G., & Mantovani, A. (1985). Effects of inactivated streptococci (OK-432) on macrophage functions in mice. Journal of Immunopharmacology, 7(4), 437-449.