Abstract
The effects of inactivated streptococci (OK-432) on murine macrophage functions were investigated. In vivo treatment of peritoneal macrophages with OK-432 augmented the direct cytotoxic activity against TU5 tumor cells in a 48 h tritiated thymidine release assay. OK-432 also stimulated the rapid (6 h, 51Cr release) macrophage-mediated killing of Actinomycin D-sensitized WEHI 164 sarcoma cells. Moreover, the expression of Ia antigens on peritoneal macrophages was found to be greatly enhanced after in vivo treatment with OK-432. The immunomodulatory effects of OK-432 on macrophages functions may contribute to the antitumor activity of inactivated streptococci.
| Original language | English |
|---|---|
| Pages (from-to) | 437-449 |
| Number of pages | 13 |
| Journal | Journal of Immunopharmacology |
| Volume | 7 |
| Issue number | 4 |
| Publication status | Published - 1985 |
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ASJC Scopus subject areas
- Immunology
- Toxicology
- Pharmacology
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Effects of inactivated streptococci (OK-432) on macrophage functions in mice. / Colotta, F.; Bersani, L.; Polentarutti, N.; Peri, G.; Mantovani, A.
In: Journal of Immunopharmacology, Vol. 7, No. 4, 1985, p. 437-449.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of inactivated streptococci (OK-432) on macrophage functions in mice
AU - Colotta, F.
AU - Bersani, L.
AU - Polentarutti, N.
AU - Peri, G.
AU - Mantovani, A.
PY - 1985
Y1 - 1985
N2 - The effects of inactivated streptococci (OK-432) on murine macrophage functions were investigated. In vivo treatment of peritoneal macrophages with OK-432 augmented the direct cytotoxic activity against TU5 tumor cells in a 48 h tritiated thymidine release assay. OK-432 also stimulated the rapid (6 h, 51Cr release) macrophage-mediated killing of Actinomycin D-sensitized WEHI 164 sarcoma cells. Moreover, the expression of Ia antigens on peritoneal macrophages was found to be greatly enhanced after in vivo treatment with OK-432. The immunomodulatory effects of OK-432 on macrophages functions may contribute to the antitumor activity of inactivated streptococci.
AB - The effects of inactivated streptococci (OK-432) on murine macrophage functions were investigated. In vivo treatment of peritoneal macrophages with OK-432 augmented the direct cytotoxic activity against TU5 tumor cells in a 48 h tritiated thymidine release assay. OK-432 also stimulated the rapid (6 h, 51Cr release) macrophage-mediated killing of Actinomycin D-sensitized WEHI 164 sarcoma cells. Moreover, the expression of Ia antigens on peritoneal macrophages was found to be greatly enhanced after in vivo treatment with OK-432. The immunomodulatory effects of OK-432 on macrophages functions may contribute to the antitumor activity of inactivated streptococci.
UR - http://www.scopus.com/inward/record.url?scp=0022370222&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022370222&partnerID=8YFLogxK
M3 - Article
VL - 7
SP - 437
EP - 449
JO - Journal of Immunopharmacology
JF - Journal of Immunopharmacology
SN - 0163-0571
IS - 4
ER -