Effects of inactivated streptococci (OK-432) on macrophage functions in mice

F. Colotta, L. Bersani, N. Polentarutti, G. Peri, A. Mantovani

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Abstract

The effects of inactivated streptococci (OK-432) on murine macrophage functions were investigated, in viva treatment of peritoneal macrophages with OK-432 augmented the direct cytotoxic activity against TU5 tumor cells in a 48 h tritiated thymidine release assay. OK-432 also stimulated the rapid (6 h, 51Cr release) macrophage-mediated killing of Actinomycin D-sensitized WEHI 164 sarcoma cells. Moreover, the expression of la antigens on peritoneal macrophages was found to be greatly enhanced after in vivo treatment with OK-432. The immunomodulatory effects of OK-432 on macrophages functions may contribute to the antitumor activity of inactivated streptococci.

Original languageEnglish
Pages (from-to)437-449
Number of pages13
JournalImmunopharmacology and Immunotoxicology
Volume7
Issue number4
DOIs
Publication statusPublished - 1985

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Picibanil
Macrophages
Streptococcus
Peritoneal Macrophages
Dactinomycin
Sarcoma
Thymidine
Tumors
Assays
Cells
Antigens
Neoplasms

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology
  • Toxicology

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Effects of inactivated streptococci (OK-432) on macrophage functions in mice. / Colotta, F.; Bersani, L.; Polentarutti, N.; Peri, G.; Mantovani, A.

In: Immunopharmacology and Immunotoxicology, Vol. 7, No. 4, 1985, p. 437-449.

Research output: Contribution to journalArticle

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