Effects of inactivated streptococci (OK-432) on macrophage functions in mice

F. Colotta; L. Bersani; N. Polentarutti; G. Peri; A. Mantovani

doi:10.3109/08923978509026486

Effects of inactivated streptococci (OK-432) on macrophage functions in mice

F. Colotta, L. Bersani, N. Polentarutti, G. Peri, A. Mantovani

Istituto Clinico Humanitas

Research output: Contribution to journal › Article

Abstract

The effects of inactivated streptococci (OK-432) on murine macrophage functions were investigated, in viva treatment of peritoneal macrophages with OK-432 augmented the direct cytotoxic activity against TU5 tumor cells in a 48 h tritiated thymidine release assay. OK-432 also stimulated the rapid (6 h, ⁵¹Cr release) macrophage-mediated killing of Actinomycin D-sensitized WEHI 164 sarcoma cells. Moreover, the expression of la antigens on peritoneal macrophages was found to be greatly enhanced after in vivo treatment with OK-432. The immunomodulatory effects of OK-432 on macrophages functions may contribute to the antitumor activity of inactivated streptococci.

Original language	English
Pages (from-to)	437-449
Number of pages	13
Journal	Immunopharmacology and Immunotoxicology
Volume	7
Issue number	4
DOIs	https://doi.org/10.3109/08923978509026486
Publication status	Published - 1985

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ASJC Scopus subject areas

Immunology
Immunology and Allergy
Pharmacology
Toxicology

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Colotta, F., Bersani, L., Polentarutti, N., Peri, G., & Mantovani, A. (1985). Effects of inactivated streptococci (OK-432) on macrophage functions in mice. Immunopharmacology and Immunotoxicology, 7(4), 437-449. https://doi.org/10.3109/08923978509026486

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10.3109/08923978509026486