Effects of inactivated streptococci (OK-432) on macrophage functions in mice

F. Colotta, L. Bersani, N. Polentarutti, G. Peri, A. Mantovani

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The effects of inactivated streptococci (OK-432) on murine macrophage functions were investigated, in viva treatment of peritoneal macrophages with OK-432 augmented the direct cytotoxic activity against TU5 tumor cells in a 48 h tritiated thymidine release assay. OK-432 also stimulated the rapid (6 h, 51Cr release) macrophage-mediated killing of Actinomycin D-sensitized WEHI 164 sarcoma cells. Moreover, the expression of la antigens on peritoneal macrophages was found to be greatly enhanced after in vivo treatment with OK-432. The immunomodulatory effects of OK-432 on macrophages functions may contribute to the antitumor activity of inactivated streptococci.

Original languageEnglish
Pages (from-to)437-449
Number of pages13
JournalImmunopharmacology and Immunotoxicology
Issue number4
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology
  • Toxicology


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