We studied the effects of glucose, insulin, and KCl infusion (GIK), on regional myocardial perfusion and function by 99m-Tc-tetrofosmin-gated SPECT. Methods - we studied 21 male patients with their first uncomplicated acute myocardial infarction (AMI). All patients underwent a rest and submaximal stress perfusion study before and after 24-hour infusion of GIK-solution (group A) or saline solution (group B). Results - Group A showed better stress tolerance and ischaemic threshold improvement after GIK infusion whilst no statistical differences were found between basal and post-infusion test in group B. At first the stress test in group A, of the 192 segments analysed, 52 (27) showed reversible perfusion defect. In group B, of 144 segments analysed, 31 (21) showed reversible perfusion defect. A postinfusion analysis in group A showed a post-GIK end-diastolic significant count improvement in 21 segments, and a post-GIK end-systolic count improvement in 22 segments. In group B, perfusion increase was observed only in 4 segments, whilst systolic thickening increase was observed only in 1 segment. Conclusion - these data demonstrate the efficacy of GIK infusion to improve regional myocardial perfusion and function mainly in segments adjacent to the recently infarcted area.
|Number of pages||7|
|Publication status||Published - Feb 1999|
- Myocardial metabolism
- Myocardial perfusion
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine