Effects of infusion of glucose-insulin-potassium on myocardial function after a recent myocardial infarction

Lidia Marano, Alberto Bestetti, Alberto Lomuscio, Luca Tagliabue, Diego Castini, Diego Tarricone, Paola Dario, Gian Luigi Tarolo, Cesare Fiorentini

Research output: Contribution to journalArticle

Abstract

We studied the effects of glucose, insulin, and KCl infusion (GIK), on regional myocardial perfusion and function by 99m-Tc-tetrofosmin-gated SPECT. Methods - we studied 21 male patients with their first uncomplicated acute myocardial infarction (AMI). All patients underwent a rest and submaximal stress perfusion study before and after 24-hour infusion of GIK-solution (group A) or saline solution (group B). Results - Group A showed better stress tolerance and ischaemic threshold improvement after GIK infusion whilst no statistical differences were found between basal and post-infusion test in group B. At first the stress test in group A, of the 192 segments analysed, 52 (27) showed reversible perfusion defect. In group B, of 144 segments analysed, 31 (21) showed reversible perfusion defect. A postinfusion analysis in group A showed a post-GIK end-diastolic significant count improvement in 21 segments, and a post-GIK end-systolic count improvement in 22 segments. In group B, perfusion increase was observed only in 4 segments, whilst systolic thickening increase was observed only in 1 segment. Conclusion - these data demonstrate the efficacy of GIK infusion to improve regional myocardial perfusion and function mainly in segments adjacent to the recently infarcted area.

Original languageEnglish
Pages (from-to)9-15
Number of pages7
JournalActa Cardiologica
Volume55
Issue number1
Publication statusPublished - Feb 1999

Keywords

  • Glucose
  • Myocardial metabolism
  • Myocardial perfusion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Marano, L., Bestetti, A., Lomuscio, A., Tagliabue, L., Castini, D., Tarricone, D., Dario, P., Tarolo, G. L., & Fiorentini, C. (1999). Effects of infusion of glucose-insulin-potassium on myocardial function after a recent myocardial infarction. Acta Cardiologica, 55(1), 9-15.