Abstract
The influence of acute sleep deprivation during the first part of the night on 24-h blood pressure monitoring (ABPM) was studied in 36 never- treated mild to moderate hypertensive patients. According to a crossover design, they were randomized to have either sleep deprivation or a full night's sleep 1 week apart, during which they were monitored with ABPM. Urine samples for analysis of nocturnal urinary excretion of norepinephrine were collected. During the sleep-deprivation day, both mean 24-h blood pressure and mean 24-h heart rate were higher in comparison with those recorded during the routine workday, the difference being more pronounced during the nighttime (P <.01). Urinary excretion of norepinephrine showed a significant increase at night during sleep deprivation (P <.05). Blood pressure and heart rate significantly increased in the morning after a sleep-insufficient night (P <.05). These data suggest that lack of sleep in hypertensive patients may increase sympathetic nervous activity during the night and the following morning, leading to increased blood pressure and heart rate. This situation might represent an increased risk for both target organ damage and acute cardiovascular diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 63-68 |
| Number of pages | 6 |
| Journal | American Journal of Hypertension |
| Volume | 12 |
| Issue number | 1 I |
| DOIs | |
| Publication status | Published - 1999 |
Fingerprint
Keywords
- Ambulatory blood pressure monitoring
- Hypertension
- Sleep deprivation
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Effects of insufficient sleep on blood pressure in hypertensive patients : A 24-h study. / Lusardi, P.; Zoppi, A.; Preti, P.; Pesce, R. M.; Piazza, E.; Fogari, R.
In: American Journal of Hypertension, Vol. 12, No. 1 I, 1999, p. 63-68.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of insufficient sleep on blood pressure in hypertensive patients
T2 - A 24-h study
AU - Lusardi, P.
AU - Zoppi, A.
AU - Preti, P.
AU - Pesce, R. M.
AU - Piazza, E.
AU - Fogari, R.
PY - 1999
Y1 - 1999
N2 - The influence of acute sleep deprivation during the first part of the night on 24-h blood pressure monitoring (ABPM) was studied in 36 never- treated mild to moderate hypertensive patients. According to a crossover design, they were randomized to have either sleep deprivation or a full night's sleep 1 week apart, during which they were monitored with ABPM. Urine samples for analysis of nocturnal urinary excretion of norepinephrine were collected. During the sleep-deprivation day, both mean 24-h blood pressure and mean 24-h heart rate were higher in comparison with those recorded during the routine workday, the difference being more pronounced during the nighttime (P <.01). Urinary excretion of norepinephrine showed a significant increase at night during sleep deprivation (P <.05). Blood pressure and heart rate significantly increased in the morning after a sleep-insufficient night (P <.05). These data suggest that lack of sleep in hypertensive patients may increase sympathetic nervous activity during the night and the following morning, leading to increased blood pressure and heart rate. This situation might represent an increased risk for both target organ damage and acute cardiovascular diseases.
AB - The influence of acute sleep deprivation during the first part of the night on 24-h blood pressure monitoring (ABPM) was studied in 36 never- treated mild to moderate hypertensive patients. According to a crossover design, they were randomized to have either sleep deprivation or a full night's sleep 1 week apart, during which they were monitored with ABPM. Urine samples for analysis of nocturnal urinary excretion of norepinephrine were collected. During the sleep-deprivation day, both mean 24-h blood pressure and mean 24-h heart rate were higher in comparison with those recorded during the routine workday, the difference being more pronounced during the nighttime (P <.01). Urinary excretion of norepinephrine showed a significant increase at night during sleep deprivation (P <.05). Blood pressure and heart rate significantly increased in the morning after a sleep-insufficient night (P <.05). These data suggest that lack of sleep in hypertensive patients may increase sympathetic nervous activity during the night and the following morning, leading to increased blood pressure and heart rate. This situation might represent an increased risk for both target organ damage and acute cardiovascular diseases.
KW - Ambulatory blood pressure monitoring
KW - Hypertension
KW - Sleep deprivation
UR - http://www.scopus.com/inward/record.url?scp=0033017930&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033017930&partnerID=8YFLogxK
U2 - 10.1016/S0895-7061(98)00200-3
DO - 10.1016/S0895-7061(98)00200-3
M3 - Article
C2 - 10075386
AN - SCOPUS:0033017930
VL - 12
SP - 63
EP - 68
JO - American Journal of Hypertension
JF - American Journal of Hypertension
SN - 0895-7061
IS - 1 I
ER -