Effects of intra-VTA injection of neurotensin on local cerebral glucose utilization in freely moving rats

Francesco E. Pontieri, Maurizia Rasura, Alessandra Scontrini, Francesca R. Buttarelli

Research output: Contribution to journalArticlepeer-review

Abstract

The [14C]2-deoxyglucose method was applied to measure the effects of the injection of neurotensin (7 μg) in the ventral tegmental area on local cerebral glucose utilization in the rat. Injection of neurotensin produced significant increases of glucose utilization in the shell of the nucleus accumbens and in the olfactory tubercle. These results indicate that stimulation of neurotensin receptors in the ventral tegmental area produces functional changes that are confined to the regions receiving mesolimbic projections within the rostral extended amygdaloid complex. These findings extend our understanding on the effects of neurotensin in the limbic system, with particular regard to reward pathways. (C) 2000 Published by Elsevier Science Inc.

Original languageEnglish
Pages (from-to)1751-1753
Number of pages3
JournalPeptides
Volume21
Issue number11
DOIs
Publication statusPublished - 2000

Keywords

  • Cerebral metabolism
  • Deoxyglucose
  • Dopaminergic system
  • Mesolimbic pathways
  • Neuropeptides
  • Nucleus accumbens
  • Shell

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

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