Effects of intracellular acidosis on endothelial function: An overview

Ettore Crimi, Fabio Silvio Taccone, Teresa Infante, Sabino Scolletta, Valeria Crudele, Claudio Napoli

Research output: Contribution to journalArticlepeer-review


The endothelium represents the largest functional organ in the human body playing an active role in vasoregulation, coagulation, inflammation, and microvascular permeability. Endothelium contributes to maintain vascular integrity, intravascular volume, and tissue oxygenation promoting inflammatory network response for local defense and repair. Acid-basis homeostasis is an important physiologic parameter that controls cell function, and changes in pH can influence vascular tone by regulating endothelium and vascular smooth muscle cells. This review presents a current perspective of the effects of intracellular acidosis on the function and the basic regulatory mechanisms of endothelial cells.

Original languageEnglish
Pages (from-to)108-118
Number of pages11
JournalJournal of Critical Care
Issue number2
Publication statusPublished - Apr 2012


  • Acidosis
  • Endothelium
  • Intracellular
  • PH
  • Regulation

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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