Effects of intravenous disopyramide on myocardial function in patients with different degrees of cardiac failure

M. Chiariello, G. Ferro, V. Santinelli, M. G. Tari, L. Spinelli, M. Condorelli

Research output: Contribution to journalArticle

Abstract

The effects of intravenous disopyramide phosphate on myocardial function were evaluated by non-invasive indices of cardiac performance (systolic time intervals STI) in 15 patients with atherosclerotic heart disease and different degrees of cardiac failure. Disopyramide (1.5 mg/Kg) was given intravenously over a period of 5 min. This drug induced in patients in I-II classes of NYHA a significant decrease of LVETc, while PEP, ICT, and PEP/LVET ratio rose significantly. STI were affected much more markedly in patients in III-IV classes of NYHA. Particularly affected were contractility indices (PEP, ICT, PEP/LVET), which were reduced significantly more in patients in III-IV classes as compared to patients in I-II classes. In contrast, LVETc, which correlates to stroke volume and cardiac output, was similarly worsened by the drug in the 2 groups of patients. Therefore, this study shows that disopyramide has relevant depressant effects on myocardial performance, simultaneously reducing stroke volume and contractility, and that the effect on contractility is more marked in patients with severe left ventricular impairment.

Original languageEnglish
Pages (from-to)197-203
Number of pages7
JournalJapanese Heart Journal
Volume21
Issue number2
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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