Effects of ionizing radiation on human conjunctival epithelial cells: A clinical and cytologic study

Edoardo Midena, Tatiana Segato, Maria Chiara Blarzino

Research output: Contribution to journalArticlepeer-review

Abstract

In order to identify early and late modifications induced by ionizing radiation on the conjunctival surface, we studied 10 patients irradiated for paranasal sinus tumors. A clinical and morphological study of conjunctival epithelium (using an impression cytology technique) was performed; 5 patients were examined during and the others after treatment. Actinic conjunctivitis and keratitis, observed during treatment, reappeared within a few months after the end of radiotherapy. At a threshold dose of 25 Gy, chronic nuclear changes and cellular surface disorganization of the conjunctival epithelium were found - these progressed and persisted. Our data support the importance of careful monitoring of such irradiated patients and the benefit of planning a prospective clinical study to evaluate the effects of available drugs (all-trans retinoic acid) in the treatment of these lesions.

Original languageEnglish
Pages (from-to)75-81
Number of pages7
JournalOphthalmologica
Volume203
Issue number2
DOIs
Publication statusPublished - 1991

Keywords

  • Conjunctival epithelium
  • Impression cytology
  • Ionizing radiation

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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