EFFETTO DELLE RADIAZIONI IONIZZANTI SULL'ATTIVITA DELLA VALIL tRNA SINTETASI ISOLATA DA FEGATO DI RATTO E DA EPATOMA 7777 DI MORRIS

Translated title of the contribution: Effects of ionizing radiations on the activity of valyl tRNA synthetase isolated from rat liver and from Morris hepatoma 7777

M. Romano, M. Cerra, M. Salvatore, A. Onorati

Research output: Contribution to journalArticle

Abstract

The effects of ionizing radiations on valyl tRNA synthetase (L-valine tRNA ligase (AMP), E.C.6.1.1.9), purified from rat liver and Morris hepatoma 7777, are reported. The results showed that: the enzymatic activity is strongly inhibited by radiation; the enzymatic inactivation is much more marked in dilute than in concentrated solutions; the inactivation of enzyme is linked to the oxidation of sulfhydryl groups indispensable to the catalytic activity of the enzyme; no substantial difference in relation to inactivation by radiation was observed between rat liver and Morris hepatoma 7777 enzymes.

Translated title of the contributionEffects of ionizing radiations on the activity of valyl tRNA synthetase isolated from rat liver and from Morris hepatoma 7777
Original languageItalian
Pages (from-to)301-306
Number of pages6
JournalTumori
Volume60
Issue number4
Publication statusPublished - 1974

ASJC Scopus subject areas

  • Cancer Research

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