TY - JOUR
T1 - Effects of ipriflavone on bone remodeling in primary hyperparathyroidism
AU - Mazzuoli, Gianfranco
AU - Romagnoli, Elisabetta
AU - Carnevale, Vincenzo
AU - Scarda, Antonella
AU - Scarnecchia, Liliana
AU - Pacitti, Maria Teresa
AU - Rosso, Rossana
AU - Minisola, Salvatore
PY - 1992
Y1 - 1992
N2 - The aim of this study was to evaluate the effects of ipriflavone treatment on bone remodeling in primary hyperparathyroidism. Nine patients, 6 females and 3 males (mean ± SD age 56 ± 12.5 years) were treated with 1200 mg/day of ipriflavone by oral administration divided in 3 daily doses. All patients were treated for 21 days; in 5 patients treatment was prolonged to 42 days. In all patients the main serum and urinary parameters of bone remodeling were evaluated. The results suggest that ipriflavone affects bone remodeling by inhibiting bone resorption without affecting bone formation. Ipriflavone is, therefore, indicated in the treatment of metabolic bone diseases characterized by a high bone turnover.
AB - The aim of this study was to evaluate the effects of ipriflavone treatment on bone remodeling in primary hyperparathyroidism. Nine patients, 6 females and 3 males (mean ± SD age 56 ± 12.5 years) were treated with 1200 mg/day of ipriflavone by oral administration divided in 3 daily doses. All patients were treated for 21 days; in 5 patients treatment was prolonged to 42 days. In all patients the main serum and urinary parameters of bone remodeling were evaluated. The results suggest that ipriflavone affects bone remodeling by inhibiting bone resorption without affecting bone formation. Ipriflavone is, therefore, indicated in the treatment of metabolic bone diseases characterized by a high bone turnover.
KW - Bone remodeling
KW - Ipriflavone
KW - Primary hyperparathyroidism
UR - http://www.scopus.com/inward/record.url?scp=0026803194&partnerID=8YFLogxK
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U2 - 10.1016/0169-6009(92)90863-9
DO - 10.1016/0169-6009(92)90863-9
M3 - Article
C2 - 1422317
AN - SCOPUS:0026803194
VL - 19
JO - Bone and Mineral
JF - Bone and Mineral
SN - 0169-6009
IS - SUPPL. 1
ER -