Effects of ischemia and reperfusion on QT dispersion during coronary angioplasty

Antonio Michelucci, Luigi Padeletti, Marco Frati, Simone Mininni, Andrea Chelucci, M. Letizia Stochino, Ignazio Simonetti, Cristina Giglioli, Massimo Margheri, Gian Franco Gensini

Research output: Contribution to journalArticlepeer-review


The effects of ischemia and reperfusion on QT interval dispersion (QTD: QT(max)-QT(min) in the 12-lead ECG) were analyzed in 15 patients (12 males, 57 ± 13 years) undergoing coronary angioplasty (PTCA). All patients had single-vessel coronary artery disease (only one ≤ 85% stenosis in a major coronary artery) and normal left ventricular function. All were in sinus rhythm with normal atrioventricular and intraventricular conduction on the surface ECG. No patient was on therapy that could affect the QT interval. The ECG was recorded (all 12 leads simultaneously) at 50 mm/s speed before the first balloon inflation, at the end of the first inflation during PTCA, and at 30' and 60' during reperfusion following the first inflation. In order to avoid ischemic preconditioning, only recordings of the first inflation were used. In each tracing QT(max) and QT(min) were evaluated. All values were rate corrected using a simple linear equation (QT linear corrected = QT + 0.154 [1-RR]). QTD increased significantly during both ischemia and reperfusion. QT(max) was not changed by ischemia and was increased by reperfusion. QT(min) was reduced by ischemia and increased by reperfusion. These results indicate that both ischemia and reperfusion alter ventricular repolarization, inducing a less homogeneous ventricular recovery pattern.

Original languageEnglish
Pages (from-to)1905-1908
Number of pages4
JournalPACE - Pacing and Clinical Electrophysiology
Issue number11 II
Publication statusPublished - 1996


  • coronary angioplasty
  • QT dispersion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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