Effects of isolation on activity, reactivity, excitability and aggressive behavior in two inbred strains of mice

Bert Siegfried, Enrico Alleva, Alberto Oliverio, Stefano Puglisiallegra

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

In order to investigate mechanisms of isolation-induced aggressive behavior, inbred mice of the C57BL/6 and DBA/2 strains were individually housed over a period of 8 weeks. In the DBA/2 strain only, isolation was followed by a clear increase in activity (Animex), reactivity (reactions upon tactile body stimulation), excitability (duration of EEG desynchronization elicited by tactile stimulation of the thorax area under urethane anesthesia) and intermale aggression (biting and fighting responses). The use of inbred strains of mice proved to be a useful tool for the examination of the relationship between various parameters. It is concluded that there are no clear correlations between activity, reactivity and aggressive behavior and that the resulting aggressive responses in the DBA/2 strain are likely due to the increase of excitability.

Original languageEnglish
Pages (from-to)211-218
Number of pages8
JournalBehavioural Brain Research
Volume2
Issue number2
DOIs
Publication statusPublished - 1981

Fingerprint

Inbred Strains Mice
Touch
Inbred DBA Mouse
Urethane
Aggression
Inbred C57BL Mouse
Electroencephalography
Thorax
Anesthesia

Keywords

  • activity
  • aggression
  • C57BL/6 mouse
  • DBA/2 mouse
  • excitability
  • isolation
  • reactivity

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Effects of isolation on activity, reactivity, excitability and aggressive behavior in two inbred strains of mice. / Siegfried, Bert; Alleva, Enrico; Oliverio, Alberto; Puglisiallegra, Stefano.

In: Behavioural Brain Research, Vol. 2, No. 2, 1981, p. 211-218.

Research output: Contribution to journalArticle

@article{c6e78d224a4b444fbe316c747c6634ff,
title = "Effects of isolation on activity, reactivity, excitability and aggressive behavior in two inbred strains of mice",
abstract = "In order to investigate mechanisms of isolation-induced aggressive behavior, inbred mice of the C57BL/6 and DBA/2 strains were individually housed over a period of 8 weeks. In the DBA/2 strain only, isolation was followed by a clear increase in activity (Animex), reactivity (reactions upon tactile body stimulation), excitability (duration of EEG desynchronization elicited by tactile stimulation of the thorax area under urethane anesthesia) and intermale aggression (biting and fighting responses). The use of inbred strains of mice proved to be a useful tool for the examination of the relationship between various parameters. It is concluded that there are no clear correlations between activity, reactivity and aggressive behavior and that the resulting aggressive responses in the DBA/2 strain are likely due to the increase of excitability.",
keywords = "activity, aggression, C57BL/6 mouse, DBA/2 mouse, excitability, isolation, reactivity",
author = "Bert Siegfried and Enrico Alleva and Alberto Oliverio and Stefano Puglisiallegra",
year = "1981",
doi = "10.1016/0166-4328(81)90056-5",
language = "English",
volume = "2",
pages = "211--218",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Effects of isolation on activity, reactivity, excitability and aggressive behavior in two inbred strains of mice

AU - Siegfried, Bert

AU - Alleva, Enrico

AU - Oliverio, Alberto

AU - Puglisiallegra, Stefano

PY - 1981

Y1 - 1981

N2 - In order to investigate mechanisms of isolation-induced aggressive behavior, inbred mice of the C57BL/6 and DBA/2 strains were individually housed over a period of 8 weeks. In the DBA/2 strain only, isolation was followed by a clear increase in activity (Animex), reactivity (reactions upon tactile body stimulation), excitability (duration of EEG desynchronization elicited by tactile stimulation of the thorax area under urethane anesthesia) and intermale aggression (biting and fighting responses). The use of inbred strains of mice proved to be a useful tool for the examination of the relationship between various parameters. It is concluded that there are no clear correlations between activity, reactivity and aggressive behavior and that the resulting aggressive responses in the DBA/2 strain are likely due to the increase of excitability.

AB - In order to investigate mechanisms of isolation-induced aggressive behavior, inbred mice of the C57BL/6 and DBA/2 strains were individually housed over a period of 8 weeks. In the DBA/2 strain only, isolation was followed by a clear increase in activity (Animex), reactivity (reactions upon tactile body stimulation), excitability (duration of EEG desynchronization elicited by tactile stimulation of the thorax area under urethane anesthesia) and intermale aggression (biting and fighting responses). The use of inbred strains of mice proved to be a useful tool for the examination of the relationship between various parameters. It is concluded that there are no clear correlations between activity, reactivity and aggressive behavior and that the resulting aggressive responses in the DBA/2 strain are likely due to the increase of excitability.

KW - activity

KW - aggression

KW - C57BL/6 mouse

KW - DBA/2 mouse

KW - excitability

KW - isolation

KW - reactivity

UR - http://www.scopus.com/inward/record.url?scp=0019365401&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019365401&partnerID=8YFLogxK

U2 - 10.1016/0166-4328(81)90056-5

DO - 10.1016/0166-4328(81)90056-5

M3 - Article

VL - 2

SP - 211

EP - 218

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

IS - 2

ER -