Effects of isometric exercise on the carotid baroreflex in hypertensive subjects

Giuseppe Mancia, Alberto Ferrari, Luisa Gregorini, Glanfranco Parati, Guido Pomidossi

Research output: Contribution to journalArticle

Abstract

Previous studies indicate that arterial baroreceptor modulation of heart rate is drastically reduced during static or dynamic exercise. We have investigated whether this reduction also occurs with regard to blood pressure modulation by the baroreflex. The study was performed in 19 subjects with uncomplicated untreated essential hypertension In whom blood pressure was measured intraarterially, and R-R interval was obtained by an electrocardiogram. The carotid baroreceptors were stimulated by neck suction of 30 seconds’ duration, and equal stimuli were applied at rest and during hand-grip exercise performed at 40% of the subjects’ maximal strength. Baroreceptor stimulation at rest increased R-R interval and reduced blood pressure. During hand-grip, the R-R interval responses to the baroreceptor stimulus were diminished by 61%. In contrast, the blood pressure responses were not significantly altered. Similar results were obtained when two subgroups of subjects with a lesser or greater degree of hypertension were separately considered. Thus, the carotid baroreceptor influence on blood pressure is largely preserved during exercise in contrast to the carotid baroreceptor influence on the sinus node, which is markedly impaired.

Original languageEnglish
Pages (from-to)245-250
Number of pages6
JournalHypertension
Volume4
Issue number2
Publication statusPublished - 1982

Fingerprint

Pressoreceptors
Baroreflex
Exercise
Blood Pressure
Hand Strength
Hand
Sinoatrial Node
Suction
Electrocardiography
Neck
Heart Rate
Hypertension

Keywords

  • Blood pressure
  • Carotid sinus reflex
  • Essential hypertension
  • Heart rate
  • Isometric exercise

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Mancia, G., Ferrari, A., Gregorini, L., Parati, G., & Pomidossi, G. (1982). Effects of isometric exercise on the carotid baroreflex in hypertensive subjects. Hypertension, 4(2), 245-250.

Effects of isometric exercise on the carotid baroreflex in hypertensive subjects. / Mancia, Giuseppe; Ferrari, Alberto; Gregorini, Luisa; Parati, Glanfranco; Pomidossi, Guido.

In: Hypertension, Vol. 4, No. 2, 1982, p. 245-250.

Research output: Contribution to journalArticle

Mancia, G, Ferrari, A, Gregorini, L, Parati, G & Pomidossi, G 1982, 'Effects of isometric exercise on the carotid baroreflex in hypertensive subjects', Hypertension, vol. 4, no. 2, pp. 245-250.
Mancia G, Ferrari A, Gregorini L, Parati G, Pomidossi G. Effects of isometric exercise on the carotid baroreflex in hypertensive subjects. Hypertension. 1982;4(2):245-250.
Mancia, Giuseppe ; Ferrari, Alberto ; Gregorini, Luisa ; Parati, Glanfranco ; Pomidossi, Guido. / Effects of isometric exercise on the carotid baroreflex in hypertensive subjects. In: Hypertension. 1982 ; Vol. 4, No. 2. pp. 245-250.
@article{99cb72f90c3b4cc3b567fd5dc4e434a7,
title = "Effects of isometric exercise on the carotid baroreflex in hypertensive subjects",
abstract = "Previous studies indicate that arterial baroreceptor modulation of heart rate is drastically reduced during static or dynamic exercise. We have investigated whether this reduction also occurs with regard to blood pressure modulation by the baroreflex. The study was performed in 19 subjects with uncomplicated untreated essential hypertension In whom blood pressure was measured intraarterially, and R-R interval was obtained by an electrocardiogram. The carotid baroreceptors were stimulated by neck suction of 30 seconds’ duration, and equal stimuli were applied at rest and during hand-grip exercise performed at 40{\%} of the subjects’ maximal strength. Baroreceptor stimulation at rest increased R-R interval and reduced blood pressure. During hand-grip, the R-R interval responses to the baroreceptor stimulus were diminished by 61{\%}. In contrast, the blood pressure responses were not significantly altered. Similar results were obtained when two subgroups of subjects with a lesser or greater degree of hypertension were separately considered. Thus, the carotid baroreceptor influence on blood pressure is largely preserved during exercise in contrast to the carotid baroreceptor influence on the sinus node, which is markedly impaired.",
keywords = "Blood pressure, Carotid sinus reflex, Essential hypertension, Heart rate, Isometric exercise",
author = "Giuseppe Mancia and Alberto Ferrari and Luisa Gregorini and Glanfranco Parati and Guido Pomidossi",
year = "1982",
language = "English",
volume = "4",
pages = "245--250",
journal = "Hypertension",
issn = "0194-911X",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Effects of isometric exercise on the carotid baroreflex in hypertensive subjects

AU - Mancia, Giuseppe

AU - Ferrari, Alberto

AU - Gregorini, Luisa

AU - Parati, Glanfranco

AU - Pomidossi, Guido

PY - 1982

Y1 - 1982

N2 - Previous studies indicate that arterial baroreceptor modulation of heart rate is drastically reduced during static or dynamic exercise. We have investigated whether this reduction also occurs with regard to blood pressure modulation by the baroreflex. The study was performed in 19 subjects with uncomplicated untreated essential hypertension In whom blood pressure was measured intraarterially, and R-R interval was obtained by an electrocardiogram. The carotid baroreceptors were stimulated by neck suction of 30 seconds’ duration, and equal stimuli were applied at rest and during hand-grip exercise performed at 40% of the subjects’ maximal strength. Baroreceptor stimulation at rest increased R-R interval and reduced blood pressure. During hand-grip, the R-R interval responses to the baroreceptor stimulus were diminished by 61%. In contrast, the blood pressure responses were not significantly altered. Similar results were obtained when two subgroups of subjects with a lesser or greater degree of hypertension were separately considered. Thus, the carotid baroreceptor influence on blood pressure is largely preserved during exercise in contrast to the carotid baroreceptor influence on the sinus node, which is markedly impaired.

AB - Previous studies indicate that arterial baroreceptor modulation of heart rate is drastically reduced during static or dynamic exercise. We have investigated whether this reduction also occurs with regard to blood pressure modulation by the baroreflex. The study was performed in 19 subjects with uncomplicated untreated essential hypertension In whom blood pressure was measured intraarterially, and R-R interval was obtained by an electrocardiogram. The carotid baroreceptors were stimulated by neck suction of 30 seconds’ duration, and equal stimuli were applied at rest and during hand-grip exercise performed at 40% of the subjects’ maximal strength. Baroreceptor stimulation at rest increased R-R interval and reduced blood pressure. During hand-grip, the R-R interval responses to the baroreceptor stimulus were diminished by 61%. In contrast, the blood pressure responses were not significantly altered. Similar results were obtained when two subgroups of subjects with a lesser or greater degree of hypertension were separately considered. Thus, the carotid baroreceptor influence on blood pressure is largely preserved during exercise in contrast to the carotid baroreceptor influence on the sinus node, which is markedly impaired.

KW - Blood pressure

KW - Carotid sinus reflex

KW - Essential hypertension

KW - Heart rate

KW - Isometric exercise

UR - http://www.scopus.com/inward/record.url?scp=0020031027&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020031027&partnerID=8YFLogxK

M3 - Article

C2 - 7068183

AN - SCOPUS:0020031027

VL - 4

SP - 245

EP - 250

JO - Hypertension

JF - Hypertension

SN - 0194-911X

IS - 2

ER -