Effects of isometric exercise on the carotid baroreflex in hypertensive subjects

Giuseppe Mancia, Alberto Ferrari, Luisa Gregorini, Glanfranco Parati, Guido Pomidossi

Research output: Contribution to journalArticlepeer-review


Previous studies indicate that arterial baroreceptor modulation of heart rate is drastically reduced during static or dynamic exercise. We have investigated whether this reduction also occurs with regard to blood pressure modulation by the baroreflex. The study was performed in 19 subjects with uncomplicated untreated essential hypertension In whom blood pressure was measured intraarterially, and R-R interval was obtained by an electrocardiogram. The carotid baroreceptors were stimulated by neck suction of 30 seconds’ duration, and equal stimuli were applied at rest and during hand-grip exercise performed at 40% of the subjects’ maximal strength. Baroreceptor stimulation at rest increased R-R interval and reduced blood pressure. During hand-grip, the R-R interval responses to the baroreceptor stimulus were diminished by 61%. In contrast, the blood pressure responses were not significantly altered. Similar results were obtained when two subgroups of subjects with a lesser or greater degree of hypertension were separately considered. Thus, the carotid baroreceptor influence on blood pressure is largely preserved during exercise in contrast to the carotid baroreceptor influence on the sinus node, which is markedly impaired.

Original languageEnglish
Pages (from-to)245-250
Number of pages6
Issue number2
Publication statusPublished - 1982


  • Blood pressure
  • Carotid sinus reflex
  • Essential hypertension
  • Heart rate
  • Isometric exercise

ASJC Scopus subject areas

  • Internal Medicine


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