Effects of kinin blockade on the blood pressure of salt-loaded pregnant rats

P. Madeddu, P. P. Parpaglia, M. P. Demontis, M. V. Varoni, M. C. Fattaccio, V. Anania, N. Glorioso

Research output: Contribution to journalArticlepeer-review

Abstract

We evaluated whether chronic inhibition of bradykinin B2 receptors by the long-acting antagonist D-Arg,[Hyp3, Thi5,D-Tic7,Oic8]-bradykinin (Hoe 140) affects blood pressure of salt-loaded pregnant rats. Pairs of rats fed a high sodium diet (0.84 mmol sodium per gram chow) were mated at 14 weeks of age. Infusion of vehicle or Hoe 140 (300 nmol/d per kilogram body weight) was performed throughout each dam's pregnancy by use of an Alzet osmotic pump implanted in the abdominal cavity. In both groups, no significant change in systolic pressure (tail-cuff plethysmography) or renal blood flow (Doppler flowmeter) was observed from that in the unmated state to that at midterm pregnancy. In the control group, systolic pressure decreased at the 21st day of pregnancy (from 126±2 to 97±2 mm Hg, P

Original languageEnglish
Pages (from-to)823-827
Number of pages5
JournalHypertension
Volume25
Issue number4 II
Publication statusPublished - 1995

Keywords

  • blood pressure
  • hypertension, pregnancy-induced
  • kallikrein-kinin system
  • sodium, dietary

ASJC Scopus subject areas

  • Internal Medicine

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