Effects of Lactobacillus rhamnosus GG on the serotonergic pathway in a gliadin-induced enteropathy animal model

Antonella Orlando, Caterina Clemente, Benedetta D'Attoma, Francesco Russo

Research output: Contribution to journalArticlepeer-review

Abstract

The present study aimed to evaluate the effects of the probiotic Lactobacillus rhamnosus GG (L.GG) on the serotonergic pathway in an animal model of peptic tryptic digested gliadin (PTG)-induced enteropathy that mimics celiac disease (CD). The serotonin (5-HT) levels, the gene expression and the protein contents of 5-HT3B, 5-HTR4 receptors, SERT and TPH1 were evaluated in the duodenal tissue samples of control and treated Wistar rats. PTG caused an imbalance on both 5-HT receptors and SERT with a significant elevation of 5-HT levels, not due to increased synthesis by the TPH1. The L.GG counteracted the PTG-induced imbalance of the serotonergic system, reducing the 5-HTRs expression and increasing SERT without affecting TPH1 expression. Further research, also performed in clinical trials, is required to understand the precise link between 5-HT and CD. Notwithstanding, by decreasing 5-HT levels, LGG may be a potential strategy for helping improve clinical symptoms of CD.

Original languageEnglish
Article number104077
JournalJournal of Functional Foods
Volume72
DOIs
Publication statusPublished - Sep 2020

Keywords

  • 5-HT receptors
  • Celiac disease
  • Lactobacillus rhamnosus GG
  • Serotonin
  • SERT
  • TPH1

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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