Effects of lamotrigine on nocturnal sleep, daytime somnolence and cognitive functions in focal epilepsy

Fabio Placidi, M. G. Marciani, M. Diomedi, A. Scalise, F. Pauri, P. Giacomini, G. L. Gigli

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Objectives - The aim of our study was to evaluate possible changes in nocturnal sleep, daytime somnolence and cognitive functions induced by add-on therapy with lamotrigine (LTG). Material and methods - Thirteen patients affected by seizures resistant to common antiepileptic drugs (AEDs) underwent nocturnal polysomnographic monitorings, daytime somnolence evaluations and a neuropsychological battery before and after 3 months of treatment with LTG. Results - With LTG therapy we observed a significant increase in REM sleep and a significant reduction in the number of entries into REM and stage shifts. No significant correlation was observed between the decrease in nocturnal epileptiform activity and the increase in REM sleep. Other sleep parameters were unmodified. No significant changes were observed in daytime somnolence and in cognitive performances. Conclusion - LTG may produce positive effects on epileptic seizures and interictal abnormalities without interfering negatively on REM sleep, with improvement of sleep stability and without changes in daytime somnolence and neuropsychological performances. For these reasons it could be an important drug for improving epileptic patients' quality of life.

Original languageEnglish
Pages (from-to)81-86
Number of pages6
JournalActa Neurologica Scandinavica
Volume102
Issue number2
DOIs
Publication statusPublished - 2000

Fingerprint

Partial Epilepsy
Cognition
REM Sleep
Sleep
Anticonvulsants
Epilepsy
Seizures
Therapeutics
Quality of Life
lamotrigine
Pharmaceutical Preparations

Keywords

  • Daytime somnolence
  • Epilepsy
  • Lamotrigine
  • Sleep

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Placidi, F., Marciani, M. G., Diomedi, M., Scalise, A., Pauri, F., Giacomini, P., & Gigli, G. L. (2000). Effects of lamotrigine on nocturnal sleep, daytime somnolence and cognitive functions in focal epilepsy. Acta Neurologica Scandinavica, 102(2), 81-86. https://doi.org/10.1034/j.1600-0404.2000.102002081.x

Effects of lamotrigine on nocturnal sleep, daytime somnolence and cognitive functions in focal epilepsy. / Placidi, Fabio; Marciani, M. G.; Diomedi, M.; Scalise, A.; Pauri, F.; Giacomini, P.; Gigli, G. L.

In: Acta Neurologica Scandinavica, Vol. 102, No. 2, 2000, p. 81-86.

Research output: Contribution to journalArticle

Placidi, F, Marciani, MG, Diomedi, M, Scalise, A, Pauri, F, Giacomini, P & Gigli, GL 2000, 'Effects of lamotrigine on nocturnal sleep, daytime somnolence and cognitive functions in focal epilepsy', Acta Neurologica Scandinavica, vol. 102, no. 2, pp. 81-86. https://doi.org/10.1034/j.1600-0404.2000.102002081.x
Placidi, Fabio ; Marciani, M. G. ; Diomedi, M. ; Scalise, A. ; Pauri, F. ; Giacomini, P. ; Gigli, G. L. / Effects of lamotrigine on nocturnal sleep, daytime somnolence and cognitive functions in focal epilepsy. In: Acta Neurologica Scandinavica. 2000 ; Vol. 102, No. 2. pp. 81-86.
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