Effects of late-life caloric restriction on age-related alterations in the rat cortex and hippocampus

Claudia Tonini, Marco Segatto, Francesca Martino, Luisa Cigliano, Martina Nazzaro, Laura Barberio, Maurizio Mandalà, Valentina Pallottini

Research output: Contribution to journalArticlepeer-review


Background: A major problem of aging is the disruption of metabolic homeostasis. This is particularly relevant in the brain where it provokes neurodegeneration. Caloric restriction is a physiologic intervention known to delay the deleterious consequences of aging in several species ranging from yeast to mammals. To date, most studies on experimental models have started this dietary intervention from weaning, which is very difficult to be translated to human beings. Here, we study the effects of a more realistic dietary regimen in rats, starting at an advanced age and lasting for six months. Methods: we analyzed in the cortex and hippocampus, the proteins involved in the energetic balance of the cells, cholesterol metabolism, oxidative stress response, inflammation, synaptic impairment, and brain trophism. Results: our results suggest that caloric restriction in late life can revert only some age-related changes studied here.

Original languageEnglish
Article number232
Pages (from-to)1-12
Number of pages12
Issue number1
Publication statusPublished - Jan 2021


  • Aging
  • Caloric restriction
  • Cholesterol
  • Cortex
  • Hippocampus
  • Rats

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics


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