Effects of lexical-semantic treatment on memory in early alzheimer disease: An observer-blinded randomized controlled trial

Nela Jelcic, Annachiara Cagnin, Francesca Meneghello, Andrea Turolla, Mario Ermani, Mauro Dam

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background. Episodic memory and semantic abilities deteriorate early in Alzheimer disease (AD). Since the cognitive system includes interconnected and reciprocally influenced neuronal networks, the authors hypothesized that stimulation of lexical-semantic abilities may benefit semantically structured episodic memory. Objective. To investigate the effects of lexical-semantic stimulation (LSS) on verbal communication and episodic memory in early AD. Methods. Forty AD participants were randomized to LSS or unstructured cognitive stimulation (UCS) as control condition. Treatments lasted 3 months, 2 sections a week. The primary outcome measures were the Mini-Mental State Examination (MMSE), Boston Naming Test (BNT), Verbal Naming Test (VNT), Phonemic and Semantic Fluency, Story Recall, and Rey Auditory Verbal Learning (RAVL). Secondary outcome measures were neuropsychological tests assessing cognitive functions not stimulated by the intervention, such as attention, executive functions, and visual-spatial abilities, and the instrumental activities of daily living scale. A 6-month follow-up assessment was administered to the LSS group. Results. LSS treatment yielded significant improvements of the MMSE, BNT, VNT, Brief Story Recall, and RAVL delayed recall mean scores. Among secondary outcome measures, only working memory and the speed of a task assessing executive functions (Stroop test) improved after LSS. Unstructured cognitive stimulation intervention did not improve any cognitive domain. Six months after LSS discontinuation, the MMSE mean score remains significantly higher than the baseline value. Conclusion. LSS treatment may improve episodic memory in AD patients and may be regarded as a clinical option to counteract the cognitive decline typical of the disease.

Original languageEnglish
Pages (from-to)949-956
Number of pages8
JournalNeurorehabilitation and Neural Repair
Volume26
Issue number8
DOIs
Publication statusPublished - Oct 2012

Fingerprint

Semantics
Alzheimer Disease
Randomized Controlled Trials
Episodic Memory
Therapeutics
Verbal Learning
Aptitude
Executive Function
Outcome Assessment (Health Care)
Stroop Test
Neuropsychological Tests
Activities of Daily Living
Short-Term Memory
Cognition
Communication

Keywords

  • Alzheimer diseaSe
  • cognitive stimulation
  • lexical-semantic rehabilitation
  • mild cognitive impairment
  • working memory

ASJC Scopus subject areas

  • Clinical Neurology
  • Rehabilitation
  • Neurology

Cite this

Effects of lexical-semantic treatment on memory in early alzheimer disease : An observer-blinded randomized controlled trial. / Jelcic, Nela; Cagnin, Annachiara; Meneghello, Francesca; Turolla, Andrea; Ermani, Mario; Dam, Mauro.

In: Neurorehabilitation and Neural Repair, Vol. 26, No. 8, 10.2012, p. 949-956.

Research output: Contribution to journalArticle

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