Effects of lisuride on blink reflex habituation in parkinson disease

G. Sandrini, E. Alfonsi, E. Martignoni, R. Horowski, G. Nappi

Research output: Contribution to journalArticle

Abstract

The blink reflex presents a tendency to habituation (a gradual diminution of the amplitude of the response during repetitive stimulation). Electromyographic analysis of this reflex makes it possible to quantify this phenomenon. A lack of the habituation of the blink reflex is a typical feature of Parkinson disease. L-Dopa and amantadine, but not anticholinergic drugs, are able to partly reverse these abnormalities in blink reflex habituation to a normal pattern. Lisuride. a dopamine agonist with serotoninergic activity, has been recently proposed as antiparkinsonian agent. In our study we observed that lisuride has a positive effect on blink reflex habituation in Parkinson disease. A good correlation between the improvement of this electrophysiological parameter and clinical akinesia was seen. Mechanisms underlying the therapeutic effect of lisuride are complex, but this drug usually has a postsynaptic cflcct on D2 receptors. Our data suggest that these receptors play an important role in blink reflex habituation.

Original languageEnglish
Pages (from-to)374-379
Number of pages6
JournalEuropean Neurology
Volume24
Issue number6
DOIs
Publication statusPublished - 1985

Keywords

  • Blink reflex habituation
  • D<inf>2</inf> receptors
  • Lisuride
  • Parkinson disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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