Effects of lithium administration on central and peripheral nervous system in rats. Biochemical and morphological findings

R. Scelsi, E. Arrigoni, A. Moglia, P. Poggi, P. Tosca, F. Zerbi

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of 4 weeks' treatment with lithium chloride on the central and peripheral nervous system of Wistar albino rats was studied. Normal activity values of some brain enzymes related to energy transduction (LDH, MDH, COX, NADH-ccRT) and neurotransmission (ACHe), evaluated both in the homogenate in toto and in the crude mitochondrial fraction, were obtained. Fine changes in mitochondrial organelles and nerve processes of neurocytes were ultrastructurally observed. The peripheral nerve studies revealed in some treated rats a slight motor nerve conduction velocity impairment by electrophysiological methods, but no significant alterations in the sciatic nerve specimens examined by electron microscopy.

Original languageEnglish
Pages (from-to)213-216
Number of pages4
JournalPharmacopsychiatria
Volume14
Issue number6
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Effects of lithium administration on central and peripheral nervous system in rats. Biochemical and morphological findings'. Together they form a unique fingerprint.

Cite this