Effects of long-lasting antiepileptic therapy on brainstem auditory evoked potentials

S. Medaglini, M. Filippi, S. Smirne, L. Ferini-Strambi, M. C. Giust, A. Poggi, G. Comi

Research output: Contribution to journalArticle

Abstract

The brainstem auditory evoked potentials of 84 epileptic patients in chronic monotherapy with carba-mazepine (n = 36), phenobarbital (n = 19), Na-valproate (n = 20) or progabide (n = 9) were studied. The mean values of I-III and I-V interpeak latencies (IPLs) were respectively 2.16 ± 0.11 and 4.03 ± 0.17 in the control group, 2.31 ± 0.09 and 4.17 ± 0.16 in the valproic group, 2.30 ± 0.17 and 4.19 ± 0.20 in the carbamazepine group, 2.17 ± 0.16 and 4.10 ± 0.18 in the phenobarbital group and 2.16 ± 0.11 and 4.12 ± 0.17 in the progabide group. The prolongation of I-III and I-V IPLs was statistically significant only for the valproic acid and carbamazepine groups. Neither duration of the epilepsy and treatment and frequency of seizures nor the serum drug levels were correlated with I-V IPL values.

Original languageEnglish
Pages (from-to)104-107
Number of pages4
JournalNeuropsychobiology
Volume19
Issue number2
DOIs
Publication statusPublished - 1988

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Keywords

  • Anticonvulsant drugs
  • Brainstem auditory evoked potential
  • Carbamazepine
  • Na-valproate
  • Phenobarbital
  • Progabide

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychology(all)

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