Effects of long-term strontium ranelate treatment on vertebral fracture risk in postmenopausal women with osteoporosis

P. J. Meunier, C. Roux, S. Ortolani, M. Diaz-Curiel, J. Compston, P. Marquis, C. Cormier, G. Isaia, J. Badurski, J. D. Wark, J. Collette, J. Y. Reginster

Research output: Contribution to journalArticlepeer-review

Abstract

Vertebral fractures are a major adverse consequence of osteoporosis. In a large placebo-controlled trial in postmenopausal women with osteoporosis, strontium ranelate reduced vertebral fracture risk by 33% over 4 years, confirming the role of strontium ranelate as an effective long-term treatment in osteoporosis. Introduction: Osteoporotic vertebral fractures are associated with increased mortality, morbidity, and loss of quality-of-life (QoL). Strontium ranelate (2 g/day) was shown to prevent bone loss, increase bone strength, and reduce vertebral and peripheral fractures. The preplanned aim of this study was to evaluate long-term efficacy and safety of strontium ranelate. Methods: A total of 1,649 postmenopausal osteoporotic women were randomized to strontium ranelate or placebo for 4 years, followed by a 1-year treatment-switch period for half of the patients. Primary efficacy criterion was incidence of patients with new vertebral fractures over 4 years. Lumbar bone mineral density (BMD) and QoL were also evaluated. Results: Over 4 years, risk of vertebral fracture was reduced by 33% with strontium ranelate (risk reduction∈= ∈0.67, p∈

Original languageEnglish
Pages (from-to)1663-1673
Number of pages11
JournalOsteoporosis International
Volume20
Issue number10
DOIs
Publication statusPublished - Oct 2009

Keywords

  • Bone densitometry
  • Menopause
  • Osteoporosis treatment
  • Osteoporotic fracture
  • Strontium ranelate

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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