Effects of lonidamine on murine and human tumor cells in vitro: A morphological and biochemical study

C. De Martino; T. Battelli; M. G. Paggi; A. Nista; M. L. Marcante; S. D’Atri; W. Malorni; M. Gallo; A. Floridi

doi:10.1159/000225881

Effects of lonidamine on murine and human tumor cells in vitro: A morphological and biochemical study

C. De Martino, T. Battelli, M. G. Paggi, A. Nista, M. L. Marcante, S. D’Atri, W. Malorni, M. Gallo, A. Floridi

Research output: Contribution to journal › Article › peer-review

Abstract

Lonidamine induces in murine and human tumor cells severe morphological damage of the mitochondria and other cytoplasmic structures both ‘in vitro’ and ‘in vivo’. Biochemical studies have demonstrated that the drug decreases oxygen consumption and lactate production. The sensitivity of human tumor cells is not related to their histotype. Lonidamine’s effects on mitochondria, glycolysis, pentose phosphate pathway, and aromatase activity are discussed.

Original language	English
Pages (from-to)	15-29
Number of pages	15
Journal	Oncology
Volume	41
DOIs	https://doi.org/10.1159/000225881
Publication status	Published - 1984

Keywords

Aromatase
Glycolysis
Lonidamine
Mitochondria
Murine and human tumor cells
Pentose phosphate pathway
Ultrastructural changes

ASJC Scopus subject areas

Cancer Research
Oncology

Access to Document

10.1159/000225881

Cite this

@article{5d25d32ab9e44237ae9c3bda719a2c04,

title = "Effects of lonidamine on murine and human tumor cells in vitro: A morphological and biochemical study",

abstract = "Lonidamine induces in murine and human tumor cells severe morphological damage of the mitochondria and other cytoplasmic structures both {\textquoteleft}in vitro{\textquoteright} and {\textquoteleft}in vivo{\textquoteright}. Biochemical studies have demonstrated that the drug decreases oxygen consumption and lactate production. The sensitivity of human tumor cells is not related to their histotype. Lonidamine{\textquoteright}s effects on mitochondria, glycolysis, pentose phosphate pathway, and aromatase activity are discussed.",

keywords = "Aromatase, Glycolysis, Lonidamine, Mitochondria, Murine and human tumor cells, Pentose phosphate pathway, Ultrastructural changes",

author = "{De Martino}, C. and T. Battelli and Paggi, {M. G.} and A. Nista and Marcante, {M. L.} and S. D{\textquoteright}Atri and W. Malorni and M. Gallo and A. Floridi",

year = "1984",

doi = "10.1159/000225881",

language = "English",

volume = "41",

pages = "15--29",

journal = "Oncology",

issn = "0030-2414",

publisher = "UBM Medica Healthcare Publications",

}

TY - JOUR

T1 - Effects of lonidamine on murine and human tumor cells in vitro

T2 - A morphological and biochemical study

AU - De Martino, C.

AU - Battelli, T.

AU - Paggi, M. G.

AU - Nista, A.

AU - Marcante, M. L.

AU - D’Atri, S.

AU - Malorni, W.

AU - Gallo, M.

AU - Floridi, A.

PY - 1984

Y1 - 1984

N2 - Lonidamine induces in murine and human tumor cells severe morphological damage of the mitochondria and other cytoplasmic structures both ‘in vitro’ and ‘in vivo’. Biochemical studies have demonstrated that the drug decreases oxygen consumption and lactate production. The sensitivity of human tumor cells is not related to their histotype. Lonidamine’s effects on mitochondria, glycolysis, pentose phosphate pathway, and aromatase activity are discussed.

AB - Lonidamine induces in murine and human tumor cells severe morphological damage of the mitochondria and other cytoplasmic structures both ‘in vitro’ and ‘in vivo’. Biochemical studies have demonstrated that the drug decreases oxygen consumption and lactate production. The sensitivity of human tumor cells is not related to their histotype. Lonidamine’s effects on mitochondria, glycolysis, pentose phosphate pathway, and aromatase activity are discussed.

KW - Aromatase

KW - Glycolysis

KW - Lonidamine

KW - Mitochondria

KW - Murine and human tumor cells

KW - Pentose phosphate pathway

KW - Ultrastructural changes

UR - http://www.scopus.com/inward/record.url?scp=0021264796&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021264796&partnerID=8YFLogxK

U2 - 10.1159/000225881

DO - 10.1159/000225881

M3 - Article

C2 - 6717891

AN - SCOPUS:0021264796

VL - 41

SP - 15

EP - 29

JO - Oncology

JF - Oncology

SN - 0030-2414

ER -

Effects of lonidamine on murine and human tumor cells in vitro: A morphological and biochemical study

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this