Effects of lonidamine on murine and human tumor cells in vitro: A morphological and biochemical study

C. De Martino, T. Battelli, M. G. Paggi, A. Nista, M. L. Marcante, S. D’Atri, W. Malorni, M. Gallo, A. Floridi

Research output: Contribution to journalArticlepeer-review

Abstract

Lonidamine induces in murine and human tumor cells severe morphological damage of the mitochondria and other cytoplasmic structures both ‘in vitro’ and ‘in vivo’. Biochemical studies have demonstrated that the drug decreases oxygen consumption and lactate production. The sensitivity of human tumor cells is not related to their histotype. Lonidamine’s effects on mitochondria, glycolysis, pentose phosphate pathway, and aromatase activity are discussed.

Original languageEnglish
Pages (from-to)15-29
Number of pages15
JournalOncology
Volume41
DOIs
Publication statusPublished - 1984

Keywords

  • Aromatase
  • Glycolysis
  • Lonidamine
  • Mitochondria
  • Murine and human tumor cells
  • Pentose phosphate pathway
  • Ultrastructural changes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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