Effects of lonidamine on murine and human tumor cells in vitro

A morphological and biochemical study

C. De Martino, T. Battelli, M. G. Paggi, A. Nista, M. L. Marcante, S. D’Atri, W. Malorni, M. Gallo, A. Floridi

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Lonidamine induces in murine and human tumor cells severe morphological damage of the mitochondria and other cytoplasmic structures both ‘in vitro’ and ‘in vivo’. Biochemical studies have demonstrated that the drug decreases oxygen consumption and lactate production. The sensitivity of human tumor cells is not related to their histotype. Lonidamine’s effects on mitochondria, glycolysis, pentose phosphate pathway, and aromatase activity are discussed.

Original languageEnglish
Pages (from-to)15-29
Number of pages15
JournalOncology
Volume41
DOIs
Publication statusPublished - 1984

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Mitochondria
Cytoplasmic Structures
Pentose Phosphate Pathway
Aromatase
Glycolysis
Oxygen Consumption
Lactic Acid
Neoplasms
Pharmaceutical Preparations
lonidamine
In Vitro Techniques

Keywords

  • Aromatase
  • Glycolysis
  • Lonidamine
  • Mitochondria
  • Murine and human tumor cells
  • Pentose phosphate pathway
  • Ultrastructural changes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Effects of lonidamine on murine and human tumor cells in vitro : A morphological and biochemical study. / De Martino, C.; Battelli, T.; Paggi, M. G.; Nista, A.; Marcante, M. L.; D’Atri, S.; Malorni, W.; Gallo, M.; Floridi, A.

In: Oncology, Vol. 41, 1984, p. 15-29.

Research output: Contribution to journalArticle

De Martino, C, Battelli, T, Paggi, MG, Nista, A, Marcante, ML, D’Atri, S, Malorni, W, Gallo, M & Floridi, A 1984, 'Effects of lonidamine on murine and human tumor cells in vitro: A morphological and biochemical study', Oncology, vol. 41, pp. 15-29. https://doi.org/10.1159/000225881
De Martino, C. ; Battelli, T. ; Paggi, M. G. ; Nista, A. ; Marcante, M. L. ; D’Atri, S. ; Malorni, W. ; Gallo, M. ; Floridi, A. / Effects of lonidamine on murine and human tumor cells in vitro : A morphological and biochemical study. In: Oncology. 1984 ; Vol. 41. pp. 15-29.
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