Effects of loud noise exposure on DNA integrity in rat adrenal gland

Giada Frenzilli, Paola Lenzi, Vittoria Scarcelli, Francesco Fornai, Antonio Pellegrini, Paola Soldani, Antonio Paparelli, Marco Nigro

Research output: Contribution to journalArticle

Abstract

Loud noise is generally considered an environmental stressor causing negative effects on acoustic, cardiovascular, nervous, and endocrine systems. In this study, we investigated the effects of noise exposure on DNA integrity in rat adrenal gland evaluated by the comet assay. The exposure to loud noise (100 dBA) for 12 hr caused a significant increase of DNA damage in the adrenal gland. Genetic alterations did not decrease 24 hr after the cessation of the stimulus. We hypothesize that an imbalance of redox cell status is responsible for the induction and persistence of noise-induced cellular damage.

Original languageEnglish
Pages (from-to)1671-1672
Number of pages2
JournalEnvironmental Health Perspectives
Volume112
Issue number17
DOIs
Publication statusPublished - Dec 2004

Keywords

  • Adrenal gland
  • Comet assay
  • DNA damage
  • Loud noise
  • Rat

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health

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  • Cite this

    Frenzilli, G., Lenzi, P., Scarcelli, V., Fornai, F., Pellegrini, A., Soldani, P., Paparelli, A., & Nigro, M. (2004). Effects of loud noise exposure on DNA integrity in rat adrenal gland. Environmental Health Perspectives, 112(17), 1671-1672. https://doi.org/10.1289/ehp.7249