Effects of loud noise exposure on mouse myocardium: A comparison with the rat

Marco Gesi, Paola Lenzi, Francesco Fornai, Michela Ferrucci, Paola Soldani, Antonio Pellegrini, Antonio Paparelli

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Loud noise is an environmental stressor of everyday life, which affects different organs and apparati, in particular the cardiovascular system. We have already reported that noise exposure produces significant alterations in the rat myocardium, consisting of mitochondrial damage, which is evident as lysis of the cristae and dilution of the matrix. Since there are high similarities between mouse and human species, the aim of our study was to investigate the effects of acute noise exposure on the mouse heart. We found that noise exposure affects mouse myocardium at similar subcellular sites to those already described in the rat; nonetheless, quantitative analysis of the percentage of altered mitochondria in both species disclosed a clear difference between mouse and rat myocardium, which strongly suggests a different sensitivity to noise stimulus. We hypothesize that the species differences on the extent of myocardial alterations here observed might be due to the zonal pattern of cardiac noradrenergic receptors, which should be the final effectors for noise-induced myocardial changes.

Original languageEnglish
Pages (from-to)131-135
Number of pages5
JournalMicroscopy Research and Technique
Volume59
Issue number2
DOIs
Publication statusPublished - Oct 15 2002

Fingerprint

myocardium
rats
mice
Noise
Rats
Myocardium
Cardiovascular system
Mitochondria
Dilution
cardiovascular system
effectors
mitochondria
Cardiovascular System
Chemical analysis
interspecific variation
organs
stimuli
quantitative analysis
dilution
heart

Keywords

  • Electron microscopy
  • Mitochondria
  • Mouse
  • Myocardium
  • Noise stress

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Anatomy
  • Instrumentation

Cite this

Gesi, M., Lenzi, P., Fornai, F., Ferrucci, M., Soldani, P., Pellegrini, A., & Paparelli, A. (2002). Effects of loud noise exposure on mouse myocardium: A comparison with the rat. Microscopy Research and Technique, 59(2), 131-135. https://doi.org/10.1002/jemt.10185

Effects of loud noise exposure on mouse myocardium : A comparison with the rat. / Gesi, Marco; Lenzi, Paola; Fornai, Francesco; Ferrucci, Michela; Soldani, Paola; Pellegrini, Antonio; Paparelli, Antonio.

In: Microscopy Research and Technique, Vol. 59, No. 2, 15.10.2002, p. 131-135.

Research output: Contribution to journalArticle

Gesi, M, Lenzi, P, Fornai, F, Ferrucci, M, Soldani, P, Pellegrini, A & Paparelli, A 2002, 'Effects of loud noise exposure on mouse myocardium: A comparison with the rat', Microscopy Research and Technique, vol. 59, no. 2, pp. 131-135. https://doi.org/10.1002/jemt.10185
Gesi, Marco ; Lenzi, Paola ; Fornai, Francesco ; Ferrucci, Michela ; Soldani, Paola ; Pellegrini, Antonio ; Paparelli, Antonio. / Effects of loud noise exposure on mouse myocardium : A comparison with the rat. In: Microscopy Research and Technique. 2002 ; Vol. 59, No. 2. pp. 131-135.
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