Effects of low and high concentrations of cyclopyroxolamine on Candida albicans and Gardnerella vaginalis

F. Polatti, E. Capuzzo, F. Viazzo, R. Colleoni

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Abstract

The mechanism of action of cyclopyroxolamine (CPX) has been studied in cultures of Candida albicans. At concentrations up to 20 μg/ml CPX inhibits the synthesis of macromolecules, blocks the leucine transport through the membrane and inhibits accumulation in the cell. At concentrations higher than 20 μg/ml it alters the functional integrity of the cell membrane of the mycetes with dispersion of intracellular constituents. Ultrastructural and morphometric studies by transmission electronic microscopy and scanning electronic microscopy of Candida albicans and only scanning electronic microscopy for Gardnerella vaginalis exposed to CPX demonstrated the determining role of the cell wall as the molecular target of the drug. A damage to the cell wall by CPX also causes a decrease in the binding capacity of Candida albicans to the cells of the vaginal mucosa, which is the first step of the colonization of the tissue and clinical manifestations.

Original languageEnglish
Pages (from-to)107-114
Number of pages8
JournalItalian Journal of Gynaecology and Obstetrics
Volume10
Issue number3
Publication statusPublished - 1998

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ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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