Abstract
Nonsteroidal antiinflammatory drugs may affect blood pressure (BP) control in hypertensive patients receiving drug treatment, but data on the effects of low-dose aspirin are scanty. This study assessed the effects of chronic treatment with low doses of aspirin (100 mg/day) on clinic and - ambulatory systolic (SBP) and diastolic (DBP) BP in hypertensives on chronic, stable antihypertensive therapy. The study was conducted in the framework of the Primary Prevention Project (PPP), a randomized, controlled factorial trial on the preventive effect of aspirin or vitamin E in people with one or more cardiovascular risk factors. Fifteen Italian hypertension units studied 142 hypertensive patients (76 men, 66 women; mean age 59 ± 5.9 years) treated with different antihypertensive drugs: 71 patients were randomized to aspirin and 71 served as controls. All patients underwent a clinic BP evaluation with an automatic sphygmomanometer and a 24-h ambulatory BP monitoring, at baseline and after 3 months of aspirin treatment. At the end of the study the changes in clinic SBP and DBP were not statistically different in treated and untreated subjects. Ambulatory SBP and DBP after 3 months of aspirin treatment were similar to baseline: ΔSBP -0.5 mmHg (95% confidence intervals [CI] from -1.9 to +2.9 mm Hg) and ΔDBP -1.1 mm Hg (95% CI from -2.5 to +0.3 mm Hg). The pattern was similar in the control group. No interaction was found between aspirin and the most used antihypertensive drug classes (angiotensin converting enzyme inhibitors and calcium antagonists). Despite the relatively small sample size our results seem to exclude any significant influence of low-dose aspirin on BP control in hypertensives under treatment. (C) 2000 American Journal of Hypertension, Ltd.
| Original language | English |
|---|---|
| Pages (from-to) | 611-616 |
| Number of pages | 6 |
| Journal | American Journal of Hypertension |
| Volume | 13 |
| Issue number | 6 I |
| DOIs | |
| Publication status | Published - 2000 |
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Keywords
- Ambulatory blood pressure monitoring
- Aspirin
- Blood pressure control
- Hypertension
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Effects of low-dose aspirin on clinic and ambulatory blood pressure in treated hypertensive patients. / Avanzini, Fausto; Palumbo, Gaetana; Alli, Claudio; Roncaglioni, Maria Carla; Ronchi, Esio; Cristofari, Mario; Capra, Alberto; Rossi, Susanna; Nosotti, Lorenzo; Costantini, Carlo; Pietrofeso, Rocco.
In: American Journal of Hypertension, Vol. 13, No. 6 I, 2000, p. 611-616.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of low-dose aspirin on clinic and ambulatory blood pressure in treated hypertensive patients
AU - Avanzini, Fausto
AU - Palumbo, Gaetana
AU - Alli, Claudio
AU - Roncaglioni, Maria Carla
AU - Ronchi, Esio
AU - Cristofari, Mario
AU - Capra, Alberto
AU - Rossi, Susanna
AU - Nosotti, Lorenzo
AU - Costantini, Carlo
AU - Pietrofeso, Rocco
PY - 2000
Y1 - 2000
N2 - Nonsteroidal antiinflammatory drugs may affect blood pressure (BP) control in hypertensive patients receiving drug treatment, but data on the effects of low-dose aspirin are scanty. This study assessed the effects of chronic treatment with low doses of aspirin (100 mg/day) on clinic and - ambulatory systolic (SBP) and diastolic (DBP) BP in hypertensives on chronic, stable antihypertensive therapy. The study was conducted in the framework of the Primary Prevention Project (PPP), a randomized, controlled factorial trial on the preventive effect of aspirin or vitamin E in people with one or more cardiovascular risk factors. Fifteen Italian hypertension units studied 142 hypertensive patients (76 men, 66 women; mean age 59 ± 5.9 years) treated with different antihypertensive drugs: 71 patients were randomized to aspirin and 71 served as controls. All patients underwent a clinic BP evaluation with an automatic sphygmomanometer and a 24-h ambulatory BP monitoring, at baseline and after 3 months of aspirin treatment. At the end of the study the changes in clinic SBP and DBP were not statistically different in treated and untreated subjects. Ambulatory SBP and DBP after 3 months of aspirin treatment were similar to baseline: ΔSBP -0.5 mmHg (95% confidence intervals [CI] from -1.9 to +2.9 mm Hg) and ΔDBP -1.1 mm Hg (95% CI from -2.5 to +0.3 mm Hg). The pattern was similar in the control group. No interaction was found between aspirin and the most used antihypertensive drug classes (angiotensin converting enzyme inhibitors and calcium antagonists). Despite the relatively small sample size our results seem to exclude any significant influence of low-dose aspirin on BP control in hypertensives under treatment. (C) 2000 American Journal of Hypertension, Ltd.
AB - Nonsteroidal antiinflammatory drugs may affect blood pressure (BP) control in hypertensive patients receiving drug treatment, but data on the effects of low-dose aspirin are scanty. This study assessed the effects of chronic treatment with low doses of aspirin (100 mg/day) on clinic and - ambulatory systolic (SBP) and diastolic (DBP) BP in hypertensives on chronic, stable antihypertensive therapy. The study was conducted in the framework of the Primary Prevention Project (PPP), a randomized, controlled factorial trial on the preventive effect of aspirin or vitamin E in people with one or more cardiovascular risk factors. Fifteen Italian hypertension units studied 142 hypertensive patients (76 men, 66 women; mean age 59 ± 5.9 years) treated with different antihypertensive drugs: 71 patients were randomized to aspirin and 71 served as controls. All patients underwent a clinic BP evaluation with an automatic sphygmomanometer and a 24-h ambulatory BP monitoring, at baseline and after 3 months of aspirin treatment. At the end of the study the changes in clinic SBP and DBP were not statistically different in treated and untreated subjects. Ambulatory SBP and DBP after 3 months of aspirin treatment were similar to baseline: ΔSBP -0.5 mmHg (95% confidence intervals [CI] from -1.9 to +2.9 mm Hg) and ΔDBP -1.1 mm Hg (95% CI from -2.5 to +0.3 mm Hg). The pattern was similar in the control group. No interaction was found between aspirin and the most used antihypertensive drug classes (angiotensin converting enzyme inhibitors and calcium antagonists). Despite the relatively small sample size our results seem to exclude any significant influence of low-dose aspirin on BP control in hypertensives under treatment. (C) 2000 American Journal of Hypertension, Ltd.
KW - Ambulatory blood pressure monitoring
KW - Aspirin
KW - Blood pressure control
KW - Hypertension
UR - http://www.scopus.com/inward/record.url?scp=0033911534&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033911534&partnerID=8YFLogxK
U2 - 10.1016/S0895-7061(00)00231-4
DO - 10.1016/S0895-7061(00)00231-4
M3 - Article
C2 - 10912743
AN - SCOPUS:0033911534
VL - 13
SP - 611
EP - 616
JO - American Journal of Hypertension
JF - American Journal of Hypertension
SN - 0895-7061
IS - 6 I
ER -