Effects of low-dose heparin infusion on arterial endothelin-1 release in humans

P. M. Piatti; L. D. Monti; G. Valsecchi; M. Conti; R. Nasser; B. Guazzini; E. Fochesato; C. V. Phan; A. E. Pontiroli; G. Pozza

Effects of low-dose heparin infusion on arterial endothelin-1 release in humans

P. M. Piatti, L. D. Monti, G. Valsecchi, M. Conti, R. Nasser, B. Guazzini, E. Fochesato, C. V. Phan, A. E. Pontiroli, G. Pozza

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The aim of this study was to evaluate the effect of low- dose heparin infusion on arterialized endothelin-1 (ET-1) release in the presence of fasting or high insulin levels in healthy humans. Methods and Results: Eleven normal subjects underwent two tests in random order lasting 240 minutes. A primed (250 IU), continuous heparin (600 IU/h) infusion was performed in test 1; saline was infused in test 2 as control. At 120 minutes, a euglycemic hyperinsulinemic clamp (25 mU · kg^-1 · h^-1) was started that lasted 2 hours in both tests. Two hours after heparin infusion (test 1), ET-1 levels decreased by 32% (3.52+0.60 to 3.02+0.73 pg/mL), while nitric oxide (NO) and forearm blood flow increased by 29% and 14%, respectively. During saline infusion, ET-1, nitric oxide, and forearm blood flow remained unchanged. There was a significant interaction between the effect of decreasing ET-1 levels and the heparin treatment (F, 4.06; df, 3.30; P

Original language	English
Pages (from-to)	2703-2707
Number of pages	5
Journal	Circulation
Volume	94
Issue number	11
Publication status	Published - 1996

Keywords

endothelium-derived factors
heparin
insulin

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine

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title = "Effects of low-dose heparin infusion on arterial endothelin-1 release in humans",

abstract = "Background: The aim of this study was to evaluate the effect of low- dose heparin infusion on arterialized endothelin-1 (ET-1) release in the presence of fasting or high insulin levels in healthy humans. Methods and Results: Eleven normal subjects underwent two tests in random order lasting 240 minutes. A primed (250 IU), continuous heparin (600 IU/h) infusion was performed in test 1; saline was infused in test 2 as control. At 120 minutes, a euglycemic hyperinsulinemic clamp (25 mU · kg-1 · h-1) was started that lasted 2 hours in both tests. Two hours after heparin infusion (test 1), ET-1 levels decreased by 32% (3.52+0.60 to 3.02+0.73 pg/mL), while nitric oxide (NO) and forearm blood flow increased by 29% and 14%, respectively. During saline infusion, ET-1, nitric oxide, and forearm blood flow remained unchanged. There was a significant interaction between the effect of decreasing ET-1 levels and the heparin treatment (F, 4.06; df, 3.30; P",

keywords = "endothelium-derived factors, heparin, insulin",

author = "Piatti, {P. M.} and Monti, {L. D.} and G. Valsecchi and M. Conti and R. Nasser and B. Guazzini and E. Fochesato and Phan, {C. V.} and Pontiroli, {A. E.} and G. Pozza",

year = "1996",

language = "English",

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T1 - Effects of low-dose heparin infusion on arterial endothelin-1 release in humans

AU - Piatti, P. M.

AU - Monti, L. D.

AU - Valsecchi, G.

AU - Conti, M.

AU - Nasser, R.

AU - Guazzini, B.

AU - Fochesato, E.

AU - Phan, C. V.

AU - Pontiroli, A. E.

AU - Pozza, G.

PY - 1996

Y1 - 1996

N2 - Background: The aim of this study was to evaluate the effect of low- dose heparin infusion on arterialized endothelin-1 (ET-1) release in the presence of fasting or high insulin levels in healthy humans. Methods and Results: Eleven normal subjects underwent two tests in random order lasting 240 minutes. A primed (250 IU), continuous heparin (600 IU/h) infusion was performed in test 1; saline was infused in test 2 as control. At 120 minutes, a euglycemic hyperinsulinemic clamp (25 mU · kg-1 · h-1) was started that lasted 2 hours in both tests. Two hours after heparin infusion (test 1), ET-1 levels decreased by 32% (3.52+0.60 to 3.02+0.73 pg/mL), while nitric oxide (NO) and forearm blood flow increased by 29% and 14%, respectively. During saline infusion, ET-1, nitric oxide, and forearm blood flow remained unchanged. There was a significant interaction between the effect of decreasing ET-1 levels and the heparin treatment (F, 4.06; df, 3.30; P

AB - Background: The aim of this study was to evaluate the effect of low- dose heparin infusion on arterialized endothelin-1 (ET-1) release in the presence of fasting or high insulin levels in healthy humans. Methods and Results: Eleven normal subjects underwent two tests in random order lasting 240 minutes. A primed (250 IU), continuous heparin (600 IU/h) infusion was performed in test 1; saline was infused in test 2 as control. At 120 minutes, a euglycemic hyperinsulinemic clamp (25 mU · kg-1 · h-1) was started that lasted 2 hours in both tests. Two hours after heparin infusion (test 1), ET-1 levels decreased by 32% (3.52+0.60 to 3.02+0.73 pg/mL), while nitric oxide (NO) and forearm blood flow increased by 29% and 14%, respectively. During saline infusion, ET-1, nitric oxide, and forearm blood flow remained unchanged. There was a significant interaction between the effect of decreasing ET-1 levels and the heparin treatment (F, 4.06; df, 3.30; P

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