Abstract
Background: The aim of this study was to evaluate the effect of low- dose heparin infusion on arterialized endothelin-1 (ET-1) release in the presence of fasting or high insulin levels in healthy humans. Methods and Results: Eleven normal subjects underwent two tests in random order lasting 240 minutes. A primed (250 IU), continuous heparin (600 IU/h) infusion was performed in test 1; saline was infused in test 2 as control. At 120 minutes, a euglycemic hyperinsulinemic clamp (25 mU · kg-1 · h-1) was started that lasted 2 hours in both tests. Two hours after heparin infusion (test 1), ET-1 levels decreased by 32% (3.52+0.60 to 3.02+0.73 pg/mL), while nitric oxide (NO) and forearm blood flow increased by 29% and 14%, respectively. During saline infusion, ET-1, nitric oxide, and forearm blood flow remained unchanged. There was a significant interaction between the effect of decreasing ET-1 levels and the heparin treatment (F, 4.06; df, 3.30; P
| Original language | English |
|---|---|
| Pages (from-to) | 2703-2707 |
| Number of pages | 5 |
| Journal | Circulation |
| Volume | 94 |
| Issue number | 11 |
| Publication status | Published - 1996 |
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Keywords
- endothelium-derived factors
- heparin
- insulin
ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine
Cite this
Effects of low-dose heparin infusion on arterial endothelin-1 release in humans. / Piatti, P. M.; Monti, L. D.; Valsecchi, G.; Conti, M.; Nasser, R.; Guazzini, B.; Fochesato, E.; Phan, C. V.; Pontiroli, A. E.; Pozza, G.
In: Circulation, Vol. 94, No. 11, 1996, p. 2703-2707.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of low-dose heparin infusion on arterial endothelin-1 release in humans
AU - Piatti, P. M.
AU - Monti, L. D.
AU - Valsecchi, G.
AU - Conti, M.
AU - Nasser, R.
AU - Guazzini, B.
AU - Fochesato, E.
AU - Phan, C. V.
AU - Pontiroli, A. E.
AU - Pozza, G.
PY - 1996
Y1 - 1996
N2 - Background: The aim of this study was to evaluate the effect of low- dose heparin infusion on arterialized endothelin-1 (ET-1) release in the presence of fasting or high insulin levels in healthy humans. Methods and Results: Eleven normal subjects underwent two tests in random order lasting 240 minutes. A primed (250 IU), continuous heparin (600 IU/h) infusion was performed in test 1; saline was infused in test 2 as control. At 120 minutes, a euglycemic hyperinsulinemic clamp (25 mU · kg-1 · h-1) was started that lasted 2 hours in both tests. Two hours after heparin infusion (test 1), ET-1 levels decreased by 32% (3.52+0.60 to 3.02+0.73 pg/mL), while nitric oxide (NO) and forearm blood flow increased by 29% and 14%, respectively. During saline infusion, ET-1, nitric oxide, and forearm blood flow remained unchanged. There was a significant interaction between the effect of decreasing ET-1 levels and the heparin treatment (F, 4.06; df, 3.30; P
AB - Background: The aim of this study was to evaluate the effect of low- dose heparin infusion on arterialized endothelin-1 (ET-1) release in the presence of fasting or high insulin levels in healthy humans. Methods and Results: Eleven normal subjects underwent two tests in random order lasting 240 minutes. A primed (250 IU), continuous heparin (600 IU/h) infusion was performed in test 1; saline was infused in test 2 as control. At 120 minutes, a euglycemic hyperinsulinemic clamp (25 mU · kg-1 · h-1) was started that lasted 2 hours in both tests. Two hours after heparin infusion (test 1), ET-1 levels decreased by 32% (3.52+0.60 to 3.02+0.73 pg/mL), while nitric oxide (NO) and forearm blood flow increased by 29% and 14%, respectively. During saline infusion, ET-1, nitric oxide, and forearm blood flow remained unchanged. There was a significant interaction between the effect of decreasing ET-1 levels and the heparin treatment (F, 4.06; df, 3.30; P
KW - endothelium-derived factors
KW - heparin
KW - insulin
UR - http://www.scopus.com/inward/record.url?scp=10544256596&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=10544256596&partnerID=8YFLogxK
M3 - Article
C2 - 8941092
AN - SCOPUS:10544256596
VL - 94
SP - 2703
EP - 2707
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 11
ER -