Effects of low-dose heparin infusion on arterial endothelin-1 release in humans

P. M. Piatti, L. D. Monti, G. Valsecchi, M. Conti, R. Nasser, B. Guazzini, E. Fochesato, C. V. Phan, A. E. Pontiroli, G. Pozza

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Abstract

Background: The aim of this study was to evaluate the effect of low- dose heparin infusion on arterialized endothelin-1 (ET-1) release in the presence of fasting or high insulin levels in healthy humans. Methods and Results: Eleven normal subjects underwent two tests in random order lasting 240 minutes. A primed (250 IU), continuous heparin (600 IU/h) infusion was performed in test 1; saline was infused in test 2 as control. At 120 minutes, a euglycemic hyperinsulinemic clamp (25 mU · kg-1 · h-1) was started that lasted 2 hours in both tests. Two hours after heparin infusion (test 1), ET-1 levels decreased by 32% (3.52+0.60 to 3.02+0.73 pg/mL), while nitric oxide (NO) and forearm blood flow increased by 29% and 14%, respectively. During saline infusion, ET-1, nitric oxide, and forearm blood flow remained unchanged. There was a significant interaction between the effect of decreasing ET-1 levels and the heparin treatment (F, 4.06; df, 3.30; P

Original languageEnglish
Pages (from-to)2703-2707
Number of pages5
JournalCirculation
Volume94
Issue number11
Publication statusPublished - 1996

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Keywords

  • endothelium-derived factors
  • heparin
  • insulin

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Piatti, P. M., Monti, L. D., Valsecchi, G., Conti, M., Nasser, R., Guazzini, B., Fochesato, E., Phan, C. V., Pontiroli, A. E., & Pozza, G. (1996). Effects of low-dose heparin infusion on arterial endothelin-1 release in humans. Circulation, 94(11), 2703-2707.