Effects of low-dose heparin infusion on arterial endothelin-1 release in humans

P. M. Piatti, L. D. Monti, G. Valsecchi, M. Conti, R. Nasser, B. Guazzini, E. Fochesato, C. V. Phan, A. E. Pontiroli, G. Pozza

Research output: Contribution to journalArticle

Abstract

Background: The aim of this study was to evaluate the effect of low- dose heparin infusion on arterialized endothelin-1 (ET-1) release in the presence of fasting or high insulin levels in healthy humans. Methods and Results: Eleven normal subjects underwent two tests in random order lasting 240 minutes. A primed (250 IU), continuous heparin (600 IU/h) infusion was performed in test 1; saline was infused in test 2 as control. At 120 minutes, a euglycemic hyperinsulinemic clamp (25 mU · kg-1 · h-1) was started that lasted 2 hours in both tests. Two hours after heparin infusion (test 1), ET-1 levels decreased by 32% (3.52+0.60 to 3.02+0.73 pg/mL), while nitric oxide (NO) and forearm blood flow increased by 29% and 14%, respectively. During saline infusion, ET-1, nitric oxide, and forearm blood flow remained unchanged. There was a significant interaction between the effect of decreasing ET-1 levels and the heparin treatment (F, 4.06; df, 3.30; P

Original languageEnglish
Pages (from-to)2703-2707
Number of pages5
JournalCirculation
Volume94
Issue number11
Publication statusPublished - 1996

Fingerprint

Endothelin-1
Heparin
Forearm
Nitric Oxide
Glucose Clamp Technique
Fasting
Insulin

Keywords

  • endothelium-derived factors
  • heparin
  • insulin

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Piatti, P. M., Monti, L. D., Valsecchi, G., Conti, M., Nasser, R., Guazzini, B., ... Pozza, G. (1996). Effects of low-dose heparin infusion on arterial endothelin-1 release in humans. Circulation, 94(11), 2703-2707.

Effects of low-dose heparin infusion on arterial endothelin-1 release in humans. / Piatti, P. M.; Monti, L. D.; Valsecchi, G.; Conti, M.; Nasser, R.; Guazzini, B.; Fochesato, E.; Phan, C. V.; Pontiroli, A. E.; Pozza, G.

In: Circulation, Vol. 94, No. 11, 1996, p. 2703-2707.

Research output: Contribution to journalArticle

Piatti, PM, Monti, LD, Valsecchi, G, Conti, M, Nasser, R, Guazzini, B, Fochesato, E, Phan, CV, Pontiroli, AE & Pozza, G 1996, 'Effects of low-dose heparin infusion on arterial endothelin-1 release in humans', Circulation, vol. 94, no. 11, pp. 2703-2707.
Piatti PM, Monti LD, Valsecchi G, Conti M, Nasser R, Guazzini B et al. Effects of low-dose heparin infusion on arterial endothelin-1 release in humans. Circulation. 1996;94(11):2703-2707.
Piatti, P. M. ; Monti, L. D. ; Valsecchi, G. ; Conti, M. ; Nasser, R. ; Guazzini, B. ; Fochesato, E. ; Phan, C. V. ; Pontiroli, A. E. ; Pozza, G. / Effects of low-dose heparin infusion on arterial endothelin-1 release in humans. In: Circulation. 1996 ; Vol. 94, No. 11. pp. 2703-2707.
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