Abstract
Background: The aim of this study was to evaluate the effect of low- dose heparin infusion on arterialized endothelin-1 (ET-1) release in the presence of fasting or high insulin levels in healthy humans. Methods and Results: Eleven normal subjects underwent two tests in random order lasting 240 minutes. A primed (250 IU), continuous heparin (600 IU/h) infusion was performed in test 1; saline was infused in test 2 as control. At 120 minutes, a euglycemic hyperinsulinemic clamp (25 mU · kg-1 · h-1) was started that lasted 2 hours in both tests. Two hours after heparin infusion (test 1), ET-1 levels decreased by 32% (3.52+0.60 to 3.02+0.73 pg/mL), while nitric oxide (NO) and forearm blood flow increased by 29% and 14%, respectively. During saline infusion, ET-1, nitric oxide, and forearm blood flow remained unchanged. There was a significant interaction between the effect of decreasing ET-1 levels and the heparin treatment (F, 4.06; df, 3.30; P
Original language | English |
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Pages (from-to) | 2703-2707 |
Number of pages | 5 |
Journal | Circulation |
Volume | 94 |
Issue number | 11 |
Publication status | Published - 1996 |
Keywords
- endothelium-derived factors
- heparin
- insulin
ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine