Effects of low-sodium diet and spironolactone on portal pressure in patients with compensated cirrhosis

Juan Carlos García-Pagán, Juan Manuel Salmerón, Faust Feu, Angelo Luca, Pere Ginés, Pilar Pizcueta, Juan Claria, Carlos Piera, Vicente Arroyo, Jaume Bosch, Juan Rodés

Research output: Contribution to journalArticle

Abstract

The aim of this study was to investigate the hemodynamic effects of spironolactone associated with a low-sodium diet (n = 14) or a low-sodium diet alone (n = 9) in patients with compensated cirrhosis and portal hypertension. Spironolactone significantly reduced the plasma volume. This effect was associated with a significant reduction in the hepatic venous pressure gradient, from 17.6 ± 3.6 mm Hg to 15.3 ± 3.5 mm Hg (-13% ± 13%; p <0.01). Azygos blood flow (-20% ± 20%), cardiac output (-16.2% ± 10.5%) and mean arterial pressure (-9% ± 9%) also decreased significantly. However, there were no significant changes in hepatic blood flow. Patients receiving low-sodium diet alone experienced a mild but significant reduction in hepatic venous pressure gradient (-6.3% ± 6%) and in mean arterial pressure (-4% ± 5%). There were no significant changes in cardiac output and in hepatic or azygos blood flows. This study indicates that low-sodium diet plus administration of spironolactone reduces portal pressure and azygos blood flow in patients with compensated cirrhosis. Low-sodium diet alone only produces mild effects that are likely to be clinically irrelevant.

Original languageEnglish
Pages (from-to)1095-1099
Number of pages5
JournalHepatology
Volume19
Issue number5
DOIs
Publication statusPublished - May 1994

ASJC Scopus subject areas

  • Hepatology

Fingerprint Dive into the research topics of 'Effects of low-sodium diet and spironolactone on portal pressure in patients with compensated cirrhosis'. Together they form a unique fingerprint.

  • Cite this

    García-Pagán, J. C., Salmerón, J. M., Feu, F., Luca, A., Ginés, P., Pizcueta, P., Claria, J., Piera, C., Arroyo, V., Bosch, J., & Rodés, J. (1994). Effects of low-sodium diet and spironolactone on portal pressure in patients with compensated cirrhosis. Hepatology, 19(5), 1095-1099. https://doi.org/10.1016/0270-9139(94)90855-9