Effects of Mössbauer radiation on bone marrow cultures

I. Ortalli; G. Pedrazzi; K. Jiang; X. Zhang; C. Carlo-Stella; L. Mangoni; V. Rizzoli

doi:10.1007/BF02397314

Effects of Mössbauer radiation on bone marrow cultures

I. Ortalli, G. Pedrazzi, K. Jiang, X. Zhang, C. Carlo-Stella, L. Mangoni, V. Rizzoli

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

A low radiation dose approach to cell eradication would be highly desirable in cancer treatments in order to reduce the side ellects of conventional radiotherapy. In the present work we present a preliminary study on coltures of bone marrow mononuclear cells collected from normal subjects and patients with chronic myelogenous leukaemia (CML). Hematin (10⁴, 10^-3, 10°M) has been added to mattow culture cells which were then irradiated with a 3.7 GBq (100 mCi)⁵⁷Co/Rh Mossbauer source for 4 hours. Significant inbibition has been observed on the cell growth due to hematin and irradiatron.

Original language	English
Pages (from-to)	1267-1270
Number of pages	4
Journal	Hyperfine Interactions
Volume	71
Issue number	1-4
DOIs	https://doi.org/10.1007/BF02397314
Publication status	Published - Apr 1992

ASJC Scopus subject areas

Atomic and Molecular Physics, and Optics
Nuclear and High Energy Physics
Condensed Matter Physics
Physics and Astronomy(all)
Electronic, Optical and Magnetic Materials

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AU - Ortalli, I.

AU - Pedrazzi, G.

AU - Jiang, K.

AU - Zhang, X.

AU - Carlo-Stella, C.

AU - Mangoni, L.

AU - Rizzoli, V.

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AB - A low radiation dose approach to cell eradication would be highly desirable in cancer treatments in order to reduce the side ellects of conventional radiotherapy. In the present work we present a preliminary study on coltures of bone marrow mononuclear cells collected from normal subjects and patients with chronic myelogenous leukaemia (CML). Hematin (104, 10-3, 10°M) has been added to mattow culture cells which were then irradiated with a 3.7 GBq (100 mCi)57Co/Rh Mossbauer source for 4 hours. Significant inbibition has been observed on the cell growth due to hematin and irradiatron.

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