Effects of mechanical stimulation of the feet on gait and cardiovascular autonomic control in Parkinson's disease

Franca Barbic, Manuela Galli, Laura Dalla Vecchia, Margherita Canesi, Veronica Cimolin, Alberto Porta, Vlasta Bari, Gabriella Cerri, Franca Dipaola, Tito Bassani, Domenico Cozzolino, Gianni Pezzoli, Raffaello Furlan

Research output: Contribution to journalArticle

Abstract

Motor impairment in Parkinson's disease (PD) is partly due to defective central processing of lower limb afferents. Concomitant alterations in cardiovascular autonomic control leading to orthostatic hypotension may worsen motor ability. We evaluated whether mechanical activation of feet sensory afferents could improve gait and modify the response of cardiovascular autonomic control to stressors in 16 patients (age 66 ± 2 yr) with idiopathic PD (Hoehn & Yhar scale 2-3) on their usual therapy. Eight subjects (group A) were randomized to undergo skin pressure (0.58 ± 0.04 kg/mm2) stimulation at the hallux tip and first metatarsal joint (effective stimulation; ES) of both feet. Eight remaining patients (group B) underwent sham stimulation (SS) followed by ES. Three-dimensional movement analysis provided quantitative indexes of movement disability before (baseline) and 24 h after ES and SS. Spectral analysis of heart rate and blood pressure variability provided markers of cardiac sympatho-vagal (LF/HF) and vascular sympathetic (LFSAP) modulations. Markers were measured at rest and during 75° head-up tilt, before and 24 h after ES and SS. After ES, step length and gait velocity increased, upright rotation velocity was enhanced, and step number was decreased. After ES, LFSAP declined. The increase in LF/HF and LFSAP induced by tilt was greater than before feet stimulation. No changes in gait and autonomic parameters were observed after SS. Twenty-four hours after ES, patients with PD showed improved gait and increased cardiac and vascular sympathetic modulation during upright position compared with baseline. Conversely, SS was ineffective on both movement and autonomic parameters, indicating a site specificity effect of the stimulation.

Original languageEnglish
Pages (from-to)495-503
Number of pages9
JournalJournal of Applied Physiology
Volume116
Issue number5
DOIs
Publication statusPublished - Mar 1 2014

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Keywords

  • Cardiovascular autonomic control
  • Gait analysis
  • Parkinson's disease
  • Somatosensory feet mechanical stimulation
  • Spectral analysis

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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