Three to four months' PUVA treatment is a widely-adopted procedure to induce psoriasis remission and for the purpose of this study is called 'medium-term'. The 32 psoriatic patients considered revealed a statistically significant baseline decrease in OKT3 + (p <0.001), OKT4 + (p <0.001) and OKT8 + (p <0.001) as compared with 40 healthy controls, while OKT4/OKT8 was normal. Variance analysis within the psoriatic group failed to reveal further significant variation in the immunological parameters during the 3 months under study. Nevertheless, there was a marked trend towards a reduction in OKT4 + cells and OKT4/OKT8 as compared with baseline values after 3 months. These results suggest that 'medium-term' PUVA therapy does not statistically restore the pre-existing baseline changes in T-lymphocyte subsets of the psoriatic patients. The non-statistically significant effects as regards OKT4 + may be due to the small number of patients who reached 3 months' treatment (9 patients) but could be regarded as the first step towards the significant changes described here in long-term PUVA-treated psoriatic patients.
|Number of pages||5|
|Journal||Acta Dermato-Venereologica, Supplement|
|Publication status||Published - 1989|
- Blood T-lymphocyte subpopulations
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