Effects of medium-term PUVA therapy on peripheral T-lymphocyte subsets in sporiatic patients

G. Borroni, V. Brazzelli, A. Fietta, M. Gatti, M. Bellosta, G. Vignati, C. Zaccone, E. Berardesca, G. Rabbiosi

Research output: Contribution to journalArticlepeer-review

Abstract

Three to four months' PUVA treatment is a widely-adopted procedure to induce psoriasis remission and for the purpose of this study is called 'medium-term'. The 32 psoriatic patients considered revealed a statistically significant baseline decrease in OKT3 + (p <0.001), OKT4 + (p <0.001) and OKT8 + (p <0.001) as compared with 40 healthy controls, while OKT4/OKT8 was normal. Variance analysis within the psoriatic group failed to reveal further significant variation in the immunological parameters during the 3 months under study. Nevertheless, there was a marked trend towards a reduction in OKT4 + cells and OKT4/OKT8 as compared with baseline values after 3 months. These results suggest that 'medium-term' PUVA therapy does not statistically restore the pre-existing baseline changes in T-lymphocyte subsets of the psoriatic patients. The non-statistically significant effects as regards OKT4 + may be due to the small number of patients who reached 3 months' treatment (9 patients) but could be regarded as the first step towards the significant changes described here in long-term PUVA-treated psoriatic patients.

Original languageEnglish
Pages (from-to)125-129
Number of pages5
JournalActa Dermato-Venereologica, Supplement
Volume69
Issue number146
Publication statusPublished - 1989

Keywords

  • Blood T-lymphocyte subpopulations
  • Psoriasis
  • PUVA-therapy

ASJC Scopus subject areas

  • Dermatology

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