Effects of methamphetamine on the cerebellar cortex: A preliminary study

Michela Ferrucci, Carla L. Busceti, Alessandra Falleni, Filippo S. Giorgi, Stefano Ruggieri, Francesco Fornai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Methamphetamine (METH) targets monoamine nerve terminals and produces motor effects, which are related to changes in catecholamine activity within the basal ganglia. Cerebellum plays an important role in motor control, nonetheless only a few studies investigated the effects of METH in this area. In this article, we report preliminary results on protein expression in the cerebellum following METH administration. In particular, we focused on the rate-limiting catecholamine-synthesizing enzyme tyrosine hydroxylase (TH). By using immunoblotting, we found that METH administration produces a dose-dependent increase of TH within the cerebellar cortex of mice, which is opposite to the decrease of TH within the striatum. Further investigations are needed in order to determine the time course, the cerebellar regions, the cellular (and subcellular) compartments, and the functional role related to these effects.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages149-153
Number of pages5
Volume1074
DOIs
Publication statusPublished - Aug 2006

Publication series

NameAnnals of the New York Academy of Sciences
Volume1074
ISSN (Print)00778923
ISSN (Electronic)17496632

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Keywords

  • Cerebellum
  • Tyrosine hydroxylase
  • Western blot

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Ferrucci, M., Busceti, C. L., Falleni, A., Giorgi, F. S., Ruggieri, S., & Fornai, F. (2006). Effects of methamphetamine on the cerebellar cortex: A preliminary study. In Annals of the New York Academy of Sciences (Vol. 1074, pp. 149-153). (Annals of the New York Academy of Sciences; Vol. 1074). https://doi.org/10.1196/annals.1369.014