EFFETTI DELLA SOMMINISTRAZIONE ACUTA METOPROLOLO SULLA TOLLERANZA ALLO SFORZO DI PAZIENTI AFFETTI DA ANGINA DA SFORZO

Translated title of the contribution: Effects of metoprolol acute administration on effort tolerance in patients affected by stable effort angina. Comparison with placebo and propranolol

M. Ferratini, S. Pirelli, P. Salvade

Research output: Contribution to journalArticle

Abstract

The effects of metoprolol (S) on effort tolerance were studied in 10 patients affected by stable effort angina, by means of exercise tests with bycicle ergometer, and compared in the same patients with the effects of propranolol (I) and of placebo (P). All the patients underwent coronary arteriography by which coronary artery disease was confirmed. Placebo, propranolol and metoprolol were administered orally in a random, double blind sequence, in a dose of 870 mg (I), and 100 mg (S). The angina threshold was evaluated during several preliminary exercise tests. Thereafter an ergometric protocol able to precipitate angina in each patient between the third and the sixth minute of exercise was performed. Each treatment was preceded by a basal test and after a period of 60 to 90 minutes a second test was performed to control the efficacy of the drug. In comparison with P, S and I produced a significant increase of total work done before angina: P: 908±548 Kgm; S: 1302±609 Kgm; I: 1357±738 Kgm (S vs I, p

Translated title of the contributionEffects of metoprolol acute administration on effort tolerance in patients affected by stable effort angina. Comparison with placebo and propranolol
Original languageItalian
Pages (from-to)1358-1362
Number of pages5
JournalGiornale Italiano di Cardiologia
Volume9
Issue number12
Publication statusPublished - 1979

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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