Abstract
Background - Metoprolol provides clinical benefits in patients with congestive heart failure (CHF). In this study, we investigated the effects of controlled-release metoprolol (metoprolol CR) on clinical status, on left ventricular (LV) volumes and function, and on neurohumoral activation in a large number of patients with CHF of mixed causes. Methods and Results - Four hundred twenty-six patients with symptomatic CHF were randomized to receive metoprolol CR or placebo for 24 weeks. Metoprolol CR did not affect 6-minute walk distance, New York Heart Association functional class, or quality of life. However, there was a significant improvement in measures of LV function with an attenuation in the increase in LV end-diastolic (+23±65 mL [placebo] versus +6±61 mL, P=0.01) and LV end-systolic (+19±55 mL [placebo] versus - 2±51 mL, P
Original language | English |
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Pages (from-to) | 378-384 |
Number of pages | 7 |
Journal | Circulation |
Volume | 101 |
Issue number | 4 |
Publication status | Published - Feb 1 2000 |
Keywords
- Heart failure
- Hormones
- Receptors, adrenergic, beta
- Ventricles
ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine