Effects of MK-801 and ethanol combinations on memory consolidation in CD1 mice: Involvement of GABAergic mechanisms

Marco Aversano, Alessandro Ciamei, Vincenzo Cestari, Enrica Passino, Silvia Middei, Claudio Castellano

Research output: Contribution to journalArticle

Abstract

In the present research the effect of the noncompetitive N-methyl-D-aspartate receptor antagonist MK-801 and ethanol combinations on memory consolidation and the involvement of GABAergic mechanisms in this effect were investigated in CD1 mice injected intraperitoneally with the drugs immediately or 120 min after training in a one-trial inhibitory avoidance apparatus and tested for retention 24 h later. The results showed that (a) the retention performances of mice were impaired in a dose-dependent manner by immediate posttraining MK-801 (0.2 and 0.3, but not 0.1 mg/kg) and ethanol (1 and 2, but not 0.5 g/kg) administrations; (b) an otherwise ineffective dose of MK-801 (0.1 mg/kg) enhanced the deleterious effect exerted by ethanol (1 and 2 g/kg); (c) an otherwise ineffective dose of muscimol (0.5 mg/kg) enhanced, while otherwise ineffective doses of picrotoxin (0.25 mg/kg) or bicuculline (0.1 mg/kg) antagonized, this effect; and (d) no effect was observed when the treatments were carried out 120 min after training, suggesting that the effects observed following immediate posttraining administrations were due to the influence on the consolidation of memory. From these experiments it is evident that (a) MK-801 enhances ethanol's effects on memory consolidation and (b) GABAergic mechanisms are involved in this effect.

Original languageEnglish
Pages (from-to)327-337
Number of pages11
JournalNeurobiology of Learning and Memory
Volume77
Issue number3
DOIs
Publication statusPublished - 2002

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Keywords

  • CD1 mice
  • Ethanol
  • GABAergic drugs
  • Memory consolidation
  • MK-801
  • One-trial inhibitory avoidance

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Cognitive Neuroscience
  • Experimental and Cognitive Psychology

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