Effects of moderate salt restriction in hypertensive patients treated with oxprenolol or chlorthalidone

G. Pollavini, D. Comi, C. Grillo, M. Lombardo, O. Mantero, L. Minetti, A. Selvini, G. Suppa

Research output: Contribution to journalArticlepeer-review


Ninety-five hypertensive out-patients, whose lying diastolic blood pressure was still ≥ 95 mm Hg after a 4-week treatment with oxprenolol slow release 160 mg/day or chlorthalidone 25 mg/day, restricted their daily sodium intake for a 4-week period, while continuing to receive the previous pharmacological therapy. The dietary intervention, appositely formulated to moderately restrict sodium intake, resulted in a high patient compliance as assessed by the significant (p <0.01) reduction in the 24-hour urinary sodium excretion. At the end of the 4-week dietary period, a significant (p <0.01) decrease in lying and standing systolic and diastolic blood pressure was observed in both the oxprenolol and chlorthalidone treated groups. These results suggest that a moderate reduction in sodium intake, obtained from a low sodium diet characterized by high patient compliance and easily followed in everyday life, is effective in lowering blood pressure in hypertensive patients who do not respond satisfactorily to pharmacological therapy alone.

Original languageEnglish
Pages (from-to)451-455
Number of pages5
JournalInternational Journal of Clinical Pharmacology Therapy and Toxicology
Issue number8
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)


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