Effects of motor rehabilitation on mobility and brain plasticity in multiple sclerosis: a structural and functional MRI study

Research output: Contribution to journalArticle

Abstract

Background: Rehabilitation seems to promote brain plasticity, but objective measures of efficacy are lacking and there is a limited understanding of the mechanisms underlying functional recovery. Objective: To study functional and structural brain changes induced by gait rehabilitation. Methods: We enrolled MS inpatients (EDSS 4.5–6.5) undergoing a 4-week neurorehabilitation. Several clinical measures were obtained, including: 2-min walk test (2MWT), dynamic gait index (DGI), Berg balance scale (BBS). Furthermore, motor-task functional MRI (fMRI) of plantar dorsiflexion, resting state fMRI, and regional diffusion tensor imaging (DTI) metrics were obtained. All the assessments were performed at baseline (T0), after the end of the rehabilitation period (T1) and 3 months later (T2). Results: Twenty-nine patients were enrolled at T0, 26 at T1, and 16 completed all timepoints. At T1, there was a significant improvement of 2MWT, DGI, and BBS scores, along with a reduced extent of the widespread activation related to the motor task at the fMRI and an increased functional connectivity in the precentral and post-central gyrus, bilaterally. None of these changes were maintained at T2. Conclusions: Our findings show a short-term beneficial effect of motor rehabilitation on gait performances in MS, accompanied by brain functional reorganization in the sensory-motor network.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalJournal of Neurology
DOIs
Publication statusPublished - Jun 2018

Fingerprint

Gait
Multiple Sclerosis
Rehabilitation
Magnetic Resonance Imaging
Brain
Diffusion Tensor Imaging
Somatosensory Cortex
Inpatients
Walk Test

Keywords

  • DTI
  • fMRI
  • Multiple sclerosis
  • Plasticity
  • Rehabilitation

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

@article{bcba450fe3c94cc389f1416aac8b8da3,
title = "Effects of motor rehabilitation on mobility and brain plasticity in multiple sclerosis: a structural and functional MRI study",
abstract = "Background: Rehabilitation seems to promote brain plasticity, but objective measures of efficacy are lacking and there is a limited understanding of the mechanisms underlying functional recovery. Objective: To study functional and structural brain changes induced by gait rehabilitation. Methods: We enrolled MS inpatients (EDSS 4.5–6.5) undergoing a 4-week neurorehabilitation. Several clinical measures were obtained, including: 2-min walk test (2MWT), dynamic gait index (DGI), Berg balance scale (BBS). Furthermore, motor-task functional MRI (fMRI) of plantar dorsiflexion, resting state fMRI, and regional diffusion tensor imaging (DTI) metrics were obtained. All the assessments were performed at baseline (T0), after the end of the rehabilitation period (T1) and 3 months later (T2). Results: Twenty-nine patients were enrolled at T0, 26 at T1, and 16 completed all timepoints. At T1, there was a significant improvement of 2MWT, DGI, and BBS scores, along with a reduced extent of the widespread activation related to the motor task at the fMRI and an increased functional connectivity in the precentral and post-central gyrus, bilaterally. None of these changes were maintained at T2. Conclusions: Our findings show a short-term beneficial effect of motor rehabilitation on gait performances in MS, accompanied by brain functional reorganization in the sensory-motor network.",
keywords = "DTI, fMRI, Multiple sclerosis, Plasticity, Rehabilitation",
author = "Eleonora Tavazzi and Niels Bergsland and Davide Cattaneo and Elisa Gervasoni and Lagan{\`a}, {Maria Marcella} and Ottavia Dipasquale and Cristina Grosso and Saibene, {Francesca Lea} and Francesca Baglio and Marco Rovaris",
year = "2018",
month = "6",
doi = "10.1007/s00415-018-8859-y",
language = "English",
pages = "1--9",
journal = "Journal of Neurology",
issn = "0340-5354",
publisher = "Dr. Dietrich Steinkopff Verlag GmbH and Co. KG",

}

TY - JOUR

T1 - Effects of motor rehabilitation on mobility and brain plasticity in multiple sclerosis

T2 - a structural and functional MRI study

AU - Tavazzi, Eleonora

AU - Bergsland, Niels

AU - Cattaneo, Davide

AU - Gervasoni, Elisa

AU - Laganà, Maria Marcella

AU - Dipasquale, Ottavia

AU - Grosso, Cristina

AU - Saibene, Francesca Lea

AU - Baglio, Francesca

AU - Rovaris, Marco

PY - 2018/6

Y1 - 2018/6

N2 - Background: Rehabilitation seems to promote brain plasticity, but objective measures of efficacy are lacking and there is a limited understanding of the mechanisms underlying functional recovery. Objective: To study functional and structural brain changes induced by gait rehabilitation. Methods: We enrolled MS inpatients (EDSS 4.5–6.5) undergoing a 4-week neurorehabilitation. Several clinical measures were obtained, including: 2-min walk test (2MWT), dynamic gait index (DGI), Berg balance scale (BBS). Furthermore, motor-task functional MRI (fMRI) of plantar dorsiflexion, resting state fMRI, and regional diffusion tensor imaging (DTI) metrics were obtained. All the assessments were performed at baseline (T0), after the end of the rehabilitation period (T1) and 3 months later (T2). Results: Twenty-nine patients were enrolled at T0, 26 at T1, and 16 completed all timepoints. At T1, there was a significant improvement of 2MWT, DGI, and BBS scores, along with a reduced extent of the widespread activation related to the motor task at the fMRI and an increased functional connectivity in the precentral and post-central gyrus, bilaterally. None of these changes were maintained at T2. Conclusions: Our findings show a short-term beneficial effect of motor rehabilitation on gait performances in MS, accompanied by brain functional reorganization in the sensory-motor network.

AB - Background: Rehabilitation seems to promote brain plasticity, but objective measures of efficacy are lacking and there is a limited understanding of the mechanisms underlying functional recovery. Objective: To study functional and structural brain changes induced by gait rehabilitation. Methods: We enrolled MS inpatients (EDSS 4.5–6.5) undergoing a 4-week neurorehabilitation. Several clinical measures were obtained, including: 2-min walk test (2MWT), dynamic gait index (DGI), Berg balance scale (BBS). Furthermore, motor-task functional MRI (fMRI) of plantar dorsiflexion, resting state fMRI, and regional diffusion tensor imaging (DTI) metrics were obtained. All the assessments were performed at baseline (T0), after the end of the rehabilitation period (T1) and 3 months later (T2). Results: Twenty-nine patients were enrolled at T0, 26 at T1, and 16 completed all timepoints. At T1, there was a significant improvement of 2MWT, DGI, and BBS scores, along with a reduced extent of the widespread activation related to the motor task at the fMRI and an increased functional connectivity in the precentral and post-central gyrus, bilaterally. None of these changes were maintained at T2. Conclusions: Our findings show a short-term beneficial effect of motor rehabilitation on gait performances in MS, accompanied by brain functional reorganization in the sensory-motor network.

KW - DTI

KW - fMRI

KW - Multiple sclerosis

KW - Plasticity

KW - Rehabilitation

UR - http://www.scopus.com/inward/record.url?scp=85045040865&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85045040865&partnerID=8YFLogxK

U2 - 10.1007/s00415-018-8859-y

DO - 10.1007/s00415-018-8859-y

M3 - Article

AN - SCOPUS:85045040865

SP - 1

EP - 9

JO - Journal of Neurology

JF - Journal of Neurology

SN - 0340-5354

ER -