Abstract
Background: The suggested hypothesis of a direct anti-inflammatory property of mud-pack treatment has led us to speculate that its action on the cytokine network might counteract the heat-stress-related effects on platelet and endothelial cell function often reported following hot-spring baths. Therefore, the present study was designed to investigate the effects of a cycle of 12 daily mud-pack treatments on bio-humoral markers of inflammation, as well as on markers of in vivo platelet and/or endothelial cell activation, in plasma samples obtained from healthy volunteers. Methods: Blood samples were obtained before (T0), at the end of the first treatment (T1) and after a cycle of 12 daily mud-pack treatments (T2). Plasma cytokines (TNF-α IL-1β, and IL-6) and adhesion molecules (sP-selectin, sE-selectin and sVCAM) levels, as well as hematocrit and complete and differential blood cell counts were determined at every time point. Results: Plasma sP-selectin levels were not modified during treatment, as were not sE-selectin or sVCAM. Similarly, IL-1β and TNF-α levels were unchanged through a 12 daily mud-pack treatment. Conversely, plasma IL-6 levels were significantly lowered at the end of a 20-min 47°C mud-pack treatment (p
| Original language | English |
|---|---|
| Pages (from-to) | 209-214 |
| Number of pages | 6 |
| Journal | Clinica Chimica Acta |
| Volume | 314 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 2001 |
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Keywords
- Adhesion molecules
- Cytokines
- Mud-pack treatment
ASJC Scopus subject areas
- Biochemistry
- Clinical Biochemistry
Cite this
Effects of mud-pack treatment on plasma cytokine and soluble adhesion molecule levels in healthy volunteers. / Basili, Stefania; Martini, Francesca; Ferroni, Patrizia; Grassi, Marcello; Sili Scavalli, Antonio; Streva, Paolina; Cusumano, Gaspare; Musca, Antonino; Battista Rini, Giovan.
In: Clinica Chimica Acta, Vol. 314, No. 1-2, 2001, p. 209-214.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of mud-pack treatment on plasma cytokine and soluble adhesion molecule levels in healthy volunteers
AU - Basili, Stefania
AU - Martini, Francesca
AU - Ferroni, Patrizia
AU - Grassi, Marcello
AU - Sili Scavalli, Antonio
AU - Streva, Paolina
AU - Cusumano, Gaspare
AU - Musca, Antonino
AU - Battista Rini, Giovan
PY - 2001
Y1 - 2001
N2 - Background: The suggested hypothesis of a direct anti-inflammatory property of mud-pack treatment has led us to speculate that its action on the cytokine network might counteract the heat-stress-related effects on platelet and endothelial cell function often reported following hot-spring baths. Therefore, the present study was designed to investigate the effects of a cycle of 12 daily mud-pack treatments on bio-humoral markers of inflammation, as well as on markers of in vivo platelet and/or endothelial cell activation, in plasma samples obtained from healthy volunteers. Methods: Blood samples were obtained before (T0), at the end of the first treatment (T1) and after a cycle of 12 daily mud-pack treatments (T2). Plasma cytokines (TNF-α IL-1β, and IL-6) and adhesion molecules (sP-selectin, sE-selectin and sVCAM) levels, as well as hematocrit and complete and differential blood cell counts were determined at every time point. Results: Plasma sP-selectin levels were not modified during treatment, as were not sE-selectin or sVCAM. Similarly, IL-1β and TNF-α levels were unchanged through a 12 daily mud-pack treatment. Conversely, plasma IL-6 levels were significantly lowered at the end of a 20-min 47°C mud-pack treatment (p
AB - Background: The suggested hypothesis of a direct anti-inflammatory property of mud-pack treatment has led us to speculate that its action on the cytokine network might counteract the heat-stress-related effects on platelet and endothelial cell function often reported following hot-spring baths. Therefore, the present study was designed to investigate the effects of a cycle of 12 daily mud-pack treatments on bio-humoral markers of inflammation, as well as on markers of in vivo platelet and/or endothelial cell activation, in plasma samples obtained from healthy volunteers. Methods: Blood samples were obtained before (T0), at the end of the first treatment (T1) and after a cycle of 12 daily mud-pack treatments (T2). Plasma cytokines (TNF-α IL-1β, and IL-6) and adhesion molecules (sP-selectin, sE-selectin and sVCAM) levels, as well as hematocrit and complete and differential blood cell counts were determined at every time point. Results: Plasma sP-selectin levels were not modified during treatment, as were not sE-selectin or sVCAM. Similarly, IL-1β and TNF-α levels were unchanged through a 12 daily mud-pack treatment. Conversely, plasma IL-6 levels were significantly lowered at the end of a 20-min 47°C mud-pack treatment (p
KW - Adhesion molecules
KW - Cytokines
KW - Mud-pack treatment
UR - http://www.scopus.com/inward/record.url?scp=0035165133&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035165133&partnerID=8YFLogxK
U2 - 10.1016/S0009-8981(01)00697-0
DO - 10.1016/S0009-8981(01)00697-0
M3 - Article
C2 - 11718697
AN - SCOPUS:0035165133
VL - 314
SP - 209
EP - 214
JO - Clinica Chimica Acta
JF - Clinica Chimica Acta
SN - 0009-8981
IS - 1-2
ER -