Effects of mud-pack treatment on plasma cytokine and soluble adhesion molecule levels in healthy volunteers

Stefania Basili, Francesca Martini, Patrizia Ferroni, Marcello Grassi, Antonio Sili Scavalli, Paolina Streva, Gaspare Cusumano, Antonino Musca, Giovan Battista Rini

Research output: Contribution to journalArticlepeer-review


Background: The suggested hypothesis of a direct anti-inflammatory property of mud-pack treatment has led us to speculate that its action on the cytokine network might counteract the heat-stress-related effects on platelet and endothelial cell function often reported following hot-spring baths. Therefore, the present study was designed to investigate the effects of a cycle of 12 daily mud-pack treatments on bio-humoral markers of inflammation, as well as on markers of in vivo platelet and/or endothelial cell activation, in plasma samples obtained from healthy volunteers. Methods: Blood samples were obtained before (T0), at the end of the first treatment (T1) and after a cycle of 12 daily mud-pack treatments (T2). Plasma cytokines (TNF-α IL-1β, and IL-6) and adhesion molecules (sP-selectin, sE-selectin and sVCAM) levels, as well as hematocrit and complete and differential blood cell counts were determined at every time point. Results: Plasma sP-selectin levels were not modified during treatment, as were not sE-selectin or sVCAM. Similarly, IL-1β and TNF-α levels were unchanged through a 12 daily mud-pack treatment. Conversely, plasma IL-6 levels were significantly lowered at the end of a 20-min 47°C mud-pack treatment (p

Original languageEnglish
Pages (from-to)209-214
Number of pages6
JournalClinica Chimica Acta
Issue number1-2
Publication statusPublished - 2001


  • Adhesion molecules
  • Cytokines
  • Mud-pack treatment

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry


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