TY - JOUR
T1 - Effects of nadolol treatment on renal and hepatic hemodynamics and function in cirrhotic patients with portal hypertension
AU - Gatta, Angelo
AU - Sacerdoti, David
AU - Merkel, Carlo
AU - Milani, Loredano
AU - Battaglia, Giorgio
AU - Zuin, Renzo
PY - 1984
Y1 - 1984
N2 - Twelve cirrhotic patients with portal hypertension and esophageal varices were treated with nadolol for 1 month, and the effects on renal and hepatic hemodynamics and function were studied. A significant decrease in cardiac output, portohepatic gradient, and effective hepatic blood flow was found, whereas mean arterial pressure, liver function, effective renal blood flow, glomerular filtration rate, and urinary sodium and potassium excretions were not affected. In seven patients esophageal varices were also reduced. A significant correlation was found between the decrease in portohepatic gradient and that in cardiac output. The percentage of cardiac output distributed to the kidneys was significantly increased after nadolol treatment. In conclusion, nadolol seems to have properties useful for the treatment of portal hypertension in patients with liver cirrhosis.
AB - Twelve cirrhotic patients with portal hypertension and esophageal varices were treated with nadolol for 1 month, and the effects on renal and hepatic hemodynamics and function were studied. A significant decrease in cardiac output, portohepatic gradient, and effective hepatic blood flow was found, whereas mean arterial pressure, liver function, effective renal blood flow, glomerular filtration rate, and urinary sodium and potassium excretions were not affected. In seven patients esophageal varices were also reduced. A significant correlation was found between the decrease in portohepatic gradient and that in cardiac output. The percentage of cardiac output distributed to the kidneys was significantly increased after nadolol treatment. In conclusion, nadolol seems to have properties useful for the treatment of portal hypertension in patients with liver cirrhosis.
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U2 - 10.1016/0002-8703(84)90602-1
DO - 10.1016/0002-8703(84)90602-1
M3 - Article
C2 - 6148880
AN - SCOPUS:0021163725
VL - 108
SP - 1167
EP - 1172
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
IS - 4 PART 2
ER -