Effects of nadolol treatment on renal and hepatic hemodynamics and function in cirrhotic patients with portal hypertension

Angelo Gatta, David Sacerdoti, Carlo Merkel, Loredano Milani, Giorgio Battaglia, Renzo Zuin

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Abstract

Twelve cirrhotic patients with portal hypertension and esophageal varices were treated with nadolol for 1 month, and the effects on renal and hepatic hemodynamics and function were studied. A significant decrease in cardiac output, portohepatic gradient, and effective hepatic blood flow was found, whereas mean arterial pressure, liver function, effective renal blood flow, glomerular filtration rate, and urinary sodium and potassium excretions were not affected. In seven patients esophageal varices were also reduced. A significant correlation was found between the decrease in portohepatic gradient and that in cardiac output. The percentage of cardiac output distributed to the kidneys was significantly increased after nadolol treatment. In conclusion, nadolol seems to have properties useful for the treatment of portal hypertension in patients with liver cirrhosis.

Original languageEnglish
Pages (from-to)1167-1172
Number of pages6
JournalAmerican Heart Journal
Volume108
Issue number4 PART 2
DOIs
Publication statusPublished - 1984

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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