To evaluate the possible role of opiate receptor dysfunction in anterior pituitary hormone secretion in liver disease we have studied the effects of naloxone, an opiate receptor antagonist, on PRL, GH, FSH, LH and TSH in basal conditions and after TRH and GnRH stimulation in 10 patients with advanced liver cirrhosis. Significantly higher basal GH, LH and TSH levels were found in cirrhotics; although PRL and TSh basal levels were higher in cirrhotics than in controls, the differences were not statistically significant. Naloxone administration did not induce significant modifications in PRL, GH, LH, FSH and TSH levels in either group. In cirrhotics, TRH plus GnRH administration induced a marked increase of serum TSH, PRL, GH and gonadotropins. Naloxone administration did not significantly modify the response curves in comparison with placebo and did not affect the paradoxical GH response to TRH observed in seven cirrhotic patients.
|Number of pages||3|
|Journal||Hormone and Metabolic Research|
|Publication status||Published - 1983|
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