Effects of naloxone administration on pituitary hormones in cirrhotic patients

M. Borzio, R. Caldara, F. Borzio, S. Bruno, M. Parodi, C. Ferrari

Research output: Contribution to journalArticle

Abstract

To evaluate the possible role of opiate receptor dysfunction in anterior pituitary hormone secretion in liver disease we have studied the effects of naloxone, an opiate receptor antagonist, on PRL, GH, FSH, LH and TSH in basal conditions and after TRH and GnRH stimulation in 10 patients with advanced liver cirrhosis. Significantly higher basal GH, LH and TSH levels were found in cirrhotics; although PRL and TSh basal levels were higher in cirrhotics than in controls, the differences were not statistically significant. Naloxone administration did not induce significant modifications in PRL, GH, LH, FSH and TSH levels in either group. In cirrhotics, TRH plus GnRH administration induced a marked increase of serum TSH, PRL, GH and gonadotropins. Naloxone administration did not significantly modify the response curves in comparison with placebo and did not affect the paradoxical GH response to TRH observed in seven cirrhotic patients.

Original languageEnglish
Pages (from-to)568-570
Number of pages3
JournalHormone and Metabolic Research
Volume15
Issue number11
Publication statusPublished - 1983

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Pituitary Hormones
Opioid Receptors
Naloxone
Gonadotropin-Releasing Hormone
Anterior Pituitary Hormones
Liver
Gonadotropins
Liver Cirrhosis
Liver Diseases
Placebos
Serum
naloxone receptor

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Borzio, M., Caldara, R., Borzio, F., Bruno, S., Parodi, M., & Ferrari, C. (1983). Effects of naloxone administration on pituitary hormones in cirrhotic patients. Hormone and Metabolic Research, 15(11), 568-570.

Effects of naloxone administration on pituitary hormones in cirrhotic patients. / Borzio, M.; Caldara, R.; Borzio, F.; Bruno, S.; Parodi, M.; Ferrari, C.

In: Hormone and Metabolic Research, Vol. 15, No. 11, 1983, p. 568-570.

Research output: Contribution to journalArticle

Borzio, M, Caldara, R, Borzio, F, Bruno, S, Parodi, M & Ferrari, C 1983, 'Effects of naloxone administration on pituitary hormones in cirrhotic patients', Hormone and Metabolic Research, vol. 15, no. 11, pp. 568-570.
Borzio, M. ; Caldara, R. ; Borzio, F. ; Bruno, S. ; Parodi, M. ; Ferrari, C. / Effects of naloxone administration on pituitary hormones in cirrhotic patients. In: Hormone and Metabolic Research. 1983 ; Vol. 15, No. 11. pp. 568-570.
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