Effects of naloxone on ethanol and acetaldehyde-induced electroencephalographic changes in rabbits

L. Manzo, A. Tartara, P. Bo, M. Maurelli, G. Mazzella, F. Savoldi

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Abstract

Rabbits treated with a single IV dose of ethanol, 0.6 g/kg, exhibited rapid EEG synchronization and behavioral changes that were reversed and, in part, prevented by the opiate antagonist, naloxone, 40 μg/kg. The continuous intracerebroventricular infusion of acetaldehyde, 10 or 120 μg/min. caused biphasic changes with EEG activation and severe bradycardia followed by overt synchrony during the post-infusion period. The results of the present study provide further evidence for the ability of naloxone to counteract some acute effects of ethanol. Moreover, they do not support a role of acetaldehyde itself as mediator of EEG changes associated with mild alcohol intoxication.

Original languageEnglish
Pages (from-to)153-161
Number of pages9
JournalSubstance and Alcohol Actions/Misuse
Volume3
Issue number3
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Medicine(all)

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    Manzo, L., Tartara, A., Bo, P., Maurelli, M., Mazzella, G., & Savoldi, F. (1982). Effects of naloxone on ethanol and acetaldehyde-induced electroencephalographic changes in rabbits. Substance and Alcohol Actions/Misuse, 3(3), 153-161.