Effects of natalizumab on oligoclonal bands in the cerebrospinal fluid of multiple sclerosis patients: A longitudinal study

R. Mancuso; D. Franciotta; M. Rovaris; D. Caputo; A. Sala; A. Hernis; S. Agostini; M. G. Calvo; M. Clerici

doi:10.1177/1352458514538111

Effects of natalizumab on oligoclonal bands in the cerebrospinal fluid of multiple sclerosis patients: A longitudinal study

R. Mancuso, D. Franciotta, M. Rovaris, D. Caputo, A. Sala, A. Hernis, S. Agostini, M. G. Calvo, M. Clerici

Research output: Contribution to journal › Article › peer-review

Abstract

Retrospective studies show that natalizumab modifies oligoclonal immunoglobulin (IgG) bands (OCBs) in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients. In this study, we prospectively analyzed both serum and CSF samples from 24 MS patients, before and after 2 years of natalizumab-based therapy. Our results showed complete (55%) or partial (27%) disappearance of the OCBs in CSF samples that were taken after 2 years of therapy. Intrathecal IgG production, represented by the IgG index and IgGLoc, was also quantitatively reduced. Our data showed that natalizumab substantially modulates both intrathecal polyclonal and oligoclonal IgG production: This effect was much more potent than was previously reported.

Original language	English
Pages (from-to)	1900-1903
Number of pages	4
Journal	Multiple Sclerosis Journal
Volume	20
Issue number	14
DOIs	https://doi.org/10.1177/1352458514538111
Publication status	Published - Dec 16 2014

Keywords

Cerebrospinal fluid
intrathecal IgG
multiple sclerosis
natalizumab
oligoclonal bands

ASJC Scopus subject areas

Clinical Neurology
Neurology

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10.1177/1352458514538111

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title = "Effects of natalizumab on oligoclonal bands in the cerebrospinal fluid of multiple sclerosis patients: A longitudinal study",

abstract = "Retrospective studies show that natalizumab modifies oligoclonal immunoglobulin (IgG) bands (OCBs) in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients. In this study, we prospectively analyzed both serum and CSF samples from 24 MS patients, before and after 2 years of natalizumab-based therapy. Our results showed complete (55%) or partial (27%) disappearance of the OCBs in CSF samples that were taken after 2 years of therapy. Intrathecal IgG production, represented by the IgG index and IgGLoc, was also quantitatively reduced. Our data showed that natalizumab substantially modulates both intrathecal polyclonal and oligoclonal IgG production: This effect was much more potent than was previously reported.",

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T1 - Effects of natalizumab on oligoclonal bands in the cerebrospinal fluid of multiple sclerosis patients

T2 - A longitudinal study

AU - Mancuso, R.

AU - Franciotta, D.

AU - Rovaris, M.

AU - Caputo, D.

AU - Sala, A.

AU - Hernis, A.

AU - Agostini, S.

AU - Calvo, M. G.

AU - Clerici, M.

PY - 2014/12/16

Y1 - 2014/12/16

N2 - Retrospective studies show that natalizumab modifies oligoclonal immunoglobulin (IgG) bands (OCBs) in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients. In this study, we prospectively analyzed both serum and CSF samples from 24 MS patients, before and after 2 years of natalizumab-based therapy. Our results showed complete (55%) or partial (27%) disappearance of the OCBs in CSF samples that were taken after 2 years of therapy. Intrathecal IgG production, represented by the IgG index and IgGLoc, was also quantitatively reduced. Our data showed that natalizumab substantially modulates both intrathecal polyclonal and oligoclonal IgG production: This effect was much more potent than was previously reported.

AB - Retrospective studies show that natalizumab modifies oligoclonal immunoglobulin (IgG) bands (OCBs) in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients. In this study, we prospectively analyzed both serum and CSF samples from 24 MS patients, before and after 2 years of natalizumab-based therapy. Our results showed complete (55%) or partial (27%) disappearance of the OCBs in CSF samples that were taken after 2 years of therapy. Intrathecal IgG production, represented by the IgG index and IgGLoc, was also quantitatively reduced. Our data showed that natalizumab substantially modulates both intrathecal polyclonal and oligoclonal IgG production: This effect was much more potent than was previously reported.

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KW - intrathecal IgG

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KW - oligoclonal bands

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Effects of natalizumab on oligoclonal bands in the cerebrospinal fluid of multiple sclerosis patients: A longitudinal study

Abstract

Keywords

ASJC Scopus subject areas

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