Effects of natalizumab on oligoclonal bands in the cerebrospinal fluid of multiple sclerosis patients: A longitudinal study

R. Mancuso, D. Franciotta, M. Rovaris, D. Caputo, A. Sala, A. Hernis, S. Agostini, M. G. Calvo, M. Clerici

Research output: Contribution to journalArticle

Abstract

Retrospective studies show that natalizumab modifies oligoclonal immunoglobulin (IgG) bands (OCBs) in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients. In this study, we prospectively analyzed both serum and CSF samples from 24 MS patients, before and after 2 years of natalizumab-based therapy. Our results showed complete (55%) or partial (27%) disappearance of the OCBs in CSF samples that were taken after 2 years of therapy. Intrathecal IgG production, represented by the IgG index and IgGLoc, was also quantitatively reduced. Our data showed that natalizumab substantially modulates both intrathecal polyclonal and oligoclonal IgG production: This effect was much more potent than was previously reported.

Original languageEnglish
Pages (from-to)1900-1903
Number of pages4
JournalMultiple Sclerosis Journal
Volume20
Issue number14
DOIs
Publication statusPublished - Dec 16 2014

Keywords

  • Cerebrospinal fluid
  • intrathecal IgG
  • multiple sclerosis
  • natalizumab
  • oligoclonal bands

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Fingerprint Dive into the research topics of 'Effects of natalizumab on oligoclonal bands in the cerebrospinal fluid of multiple sclerosis patients: A longitudinal study'. Together they form a unique fingerprint.

  • Cite this