Abstract
Retrospective studies show that natalizumab modifies oligoclonal immunoglobulin (IgG) bands (OCBs) in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients. In this study, we prospectively analyzed both serum and CSF samples from 24 MS patients, before and after 2 years of natalizumab-based therapy. Our results showed complete (55%) or partial (27%) disappearance of the OCBs in CSF samples that were taken after 2 years of therapy. Intrathecal IgG production, represented by the IgG index and IgGLoc, was also quantitatively reduced. Our data showed that natalizumab substantially modulates both intrathecal polyclonal and oligoclonal IgG production: This effect was much more potent than was previously reported.
| Original language | English |
|---|---|
| Pages (from-to) | 1900-1903 |
| Number of pages | 4 |
| Journal | Multiple Sclerosis Journal |
| Volume | 20 |
| Issue number | 14 |
| DOIs | |
| Publication status | Published - Dec 16 2014 |
Keywords
- Cerebrospinal fluid
- intrathecal IgG
- multiple sclerosis
- natalizumab
- oligoclonal bands
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
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Cite this
Mancuso, R., Franciotta, D., Rovaris, M., Caputo, D., Sala, A., Hernis, A., Agostini, S., Calvo, M. G., & Clerici, M. (2014). Effects of natalizumab on oligoclonal bands in the cerebrospinal fluid of multiple sclerosis patients: A longitudinal study. Multiple Sclerosis Journal, 20(14), 1900-1903. https://doi.org/10.1177/1352458514538111