Effects of neoadjuvant therapy on perioperative morbidity in elderly patients undergoing esophagectomy for esophageal cancer

Alberto Ruol, Giuseppe Portale, Carlo Castoro, Stefano Merigliano, Matteo Cagol, Francesco Cavallin, Vanna Chiarion Sileni, Luigi Corti, Sabrina Rampado, Mario Costantini, Ermanno Ancona

Research output: Contribution to journalArticle

Abstract

Background: The use of cytoreductive therapy followed by surgery is preferred by many centers dealing with locally advanced esophageal cancer. However, the potential for increase in mortality and morbidity rates has raised concerns on the use of chemoradiation therapy, especially in elderly patients. The aim of this study was to assess the effects of induction therapy on postoperative mortality and morbidity in elderly patients undergoing esophagectomy for locally advanced esophageal cancer at a single institution. Methods: Postoperative mortality and morbidity of patients ≥70 years old undergoing esophagectomy after neoadjuvant therapy, between January 1992 and October 2005 for cancer of the esophagus or esophagogastric junction, were compared with findings in younger patients also receiving preoperative cytoreductive treatments. Results: 818 patients underwent esophagectomy during the study period. The study population included 238 patients

Original languageEnglish
Pages (from-to)3243-3250
Number of pages8
JournalAnnals of Surgical Oncology
Volume14
Issue number11
DOIs
Publication statusPublished - Nov 2007

Keywords

  • Elderly patients
  • Esophageal cancer
  • Esophagectomy
  • Morbidity
  • Mortality
  • Neoadjuvant therapy
  • Survival

ASJC Scopus subject areas

  • Surgery
  • Oncology

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